| (+/-)-Spiroganoapplanin A, a complex polycyclic meroterpenoid dimer from Ganoderma applanatum displaying potential against Alzheimer's disease |
| Peng, XR; Luo, RC; Su, HG; Zhou, L; Ran, XQ; Guo, YR; Yao, YG ; Qiu, MH
|
| 2022
|
| 发表期刊 | ORGANIC CHEMISTRY FRONTIERS
 |
| ISSN | 2052-4129
|
| 卷号 | 9期号:11页码:3093-3101 |
| 摘要 | (+/-)-Spiroganoapplanin A (1) representing a new subtype of the Ganoderma meroterpenoid dimer with a 6/5/5/6/5/6 hexacyclic system was isolated from Ganoderma applanatum. Using spectroscopic, X ray crystallographic and electronic circular dichroism analyses, the structure of the racemic natural product was determined, and its unusual NMR behavior was investigated by variable-temperature NMR experiments. The possible biogenetic pathway for 1 was proposed. Cellular assays showed that (+/-)-1, (+)-1, and (-)-1 all reduce A beta 42 production and inhibit tau phosphorylation through BACE1, CDK5, and GSK3 beta-mediated pathways, suggesting their potential against Alzheimer's disease. |
| 收录类别 | sci
|
| 语种 | 英语
|
| 文献类型 | 期刊论文
|
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13499
|
| 专题 | 科研部门_疾病机理遗传学和进化医学学科组（姚永刚）
|
推荐引用方式
GB/T 7714 |
Peng, XR,Luo, RC,Su, HG,et al. (+/-)-Spiroganoapplanin A, a complex polycyclic meroterpenoid dimer from Ganoderma applanatum displaying potential against Alzheimer's disease[J]. ORGANIC CHEMISTRY FRONTIERS,2022,9(11):3093-3101.
|
| APA |
Peng, XR.,Luo, RC.,Su, HG.,Zhou, L.,Ran, XQ.,...&Qiu, MH.(2022).(+/-)-Spiroganoapplanin A, a complex polycyclic meroterpenoid dimer from Ganoderma applanatum displaying potential against Alzheimer's disease.ORGANIC CHEMISTRY FRONTIERS,9(11),3093-3101.
|
| MLA |
Peng, XR,et al."(+/-)-Spiroganoapplanin A, a complex polycyclic meroterpenoid dimer from Ganoderma applanatum displaying potential against Alzheimer's disease".ORGANIC CHEMISTRY FRONTIERS 9.11(2022):3093-3101.
|
修改评论