Histone Deacetylase Inhibitors (HDACi) Promote KLF5 Ubiquitination and Degradation in Basal-like Breast Cancer

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Histone Deacetylase Inhibitors (HDACi) Promote KLF5 Ubiquitination and Degradation in Basal-like Breast Cancer
	Kong, YJ; Ren, WL; Fang, H; Shah, NA; Shi, YJ; You, DY; Zhou, CG; Jiang, DW; Yang, CAY; Liang, HC; Liu, WJ; Wang, LZ; Gan, WQ; Wan, X; Li, FB; Li, Z; Chen, CS; Xie, N
	2022
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN	1449-2288
卷号	18 期号:5 页码:2104-2115
摘要	Basal-like breast cancer (BLBC) accounts for approximately 15% of all breast cancer cases, and patients with BLBC have a low survival rate. Our previous study demonstrated that the KLF5 transcription factor promotes BLBC cell proliferation and tumor growth. In this study, we demonstrated that the histone deacetylase inhibitors (HDACi), suberoylanilide hydroxamic acid (SAHA), and trichostatin A (TSA), increased KLF5 acetylation at lysine 369 (K369), downregulated KLF5 protein expression levels, and decreased cell viability in BLBC cell lines. HDACi target KLF5 for proteasomal degradation by promoting KLF5 protein ubiquitination. K369 acetylation of KLF5 decreases the binding between KLF5 and its deubiquitinase, BAP1. These findings revealed a novel mechanism by which HDACi suppress BLBC, and a novel crosstalk between KLF5 protein acetylation and ubiquitination.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13690
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Kong, YJ,Ren, WL,Fang, H,et al. Histone Deacetylase Inhibitors (HDACi) Promote KLF5 Ubiquitination and Degradation in Basal-like Breast Cancer[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2022,18(5):2104-2115.
APA	Kong, YJ.,Ren, WL.,Fang, H.,Shah, NA.,Shi, YJ.,...&Xie, N.(2022).Histone Deacetylase Inhibitors (HDACi) Promote KLF5 Ubiquitination and Degradation in Basal-like Breast Cancer.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,18(5),2104-2115.
MLA	Kong, YJ,et al."Histone Deacetylase Inhibitors (HDACi) Promote KLF5 Ubiquitination and Degradation in Basal-like Breast Cancer".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 18.5(2022):2104-2115.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2023032939.pdf（2239KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文