S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

	S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates
	Liang, JG; Su, DM; Song, TZ; Zeng, YL; Huang, WJ; Wu, JH; Xu, R; Luo, PW; Yang, XF; Zhang, XD; Luo, SR; Liang, Y; Li, XL; Huang, JJ; Wang, Q; Huang, XQ; Xu, QS; Luo, M; Huang, AL; Luo, DX; Zhao, CY; Yang, F; Han, JB; Zheng, YT; Liang, P
	2021
发表期刊	NATURE COMMUNICATIONS
卷号	12 期号:1
摘要	SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-like trimeric subunit vaccine candidate for COVID-19 based on Trimer-Tag technology. Immunization of S-Trimer with either AS03 (oil-in-water emulsion) or CpG 1018 (TLR9 agonist) plus alum adjuvants induced high-level of neutralizing antibodies and Th1-biased cellular immune responses in animal models. Moreover, rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls, based on clinical observations and reduction of viral loads in lungs. Trimer-Tag may be an important platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses. Vaccines for SARS-CoV-2 are needed to fight the pandemic. Here the authors show immunogenicity of an adjuvanted subunit vaccine, SARS-CoV-2 spike protein trimerized with trimer-tag technology, in small animal models and protection from SARS-CoV-2 challenge in non-human primates.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13836
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Liang, JG,Su, DM,Song, TZ,et al. S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates[J]. NATURE COMMUNICATIONS,2021,12(1).
APA	Liang, JG.,Su, DM.,Song, TZ.,Zeng, YL.,Huang, WJ.,...&Liang, P.(2021).S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates.NATURE COMMUNICATIONS,12(1).
MLA	Liang, JG,et al."S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates".NATURE COMMUNICATIONS 12.1(2021).

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