On the origin and evolution of RNA editing in metazoans

	On the origin and evolution of RNA editing in metazoans
	Zhang, P; Zhu, YZ; Guo, QF; Li, J; Zhan, XY; Yu, H; Xie, NX; Tan, HS; Lundholm, N; Garcia-Cuetos, L; Martin, MD; Subirats, MA; Su, YH; Ruiz-Trillo, I; Martindale, MQ; Yu, JK; Gilbert, MTP; Zhang, GJ; Li, QY
	2023
发表期刊	CELL REPORTS
ISSN	2211-1247
卷号	42 期号:2
摘要	Extensive adenosine-to-inosine (A-to-I) editing of nuclear-transcribed mRNAs is the hallmark of metazoan transcriptional regulation. Here, by profiling the RNA editomes of 22 species that cover major groups of Hol-ozoa, we provide substantial evidence supporting A-to-I mRNA editing as a regulatory innovation originating in the last common ancestor of extant metazoans. This ancient biochemistry process is preserved in most extant metazoan phyla and primarily targets endogenous double-stranded RNA (dsRNA) formed by evolution-arily young repeats. We also find intermolecular pairing of sense-antisense transcripts as an important mech-anism for forming dsRNA substrates for A-to-I editing in some but not all lineages. Likewise, recoding editing is rarely shared across lineages but preferentially targets genes involved in neural and cytoskeleton systems in bilaterians. We conclude that metazoan A-to-I editing might first emerge as a safeguard mechanism against repeat-derived dsRNA and was later co-opted into diverse biological processes due to its mutagenic nature.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14011
专题	科研部门_遗传多样性基因组学研究组（张国捷）
推荐引用方式 GB/T 7714	Zhang, P,Zhu, YZ,Guo, QF,et al. On the origin and evolution of RNA editing in metazoans[J]. CELL REPORTS,2023,42(2).
APA	Zhang, P.,Zhu, YZ.,Guo, QF.,Li, J.,Zhan, XY.,...&Li, QY.(2023).On the origin and evolution of RNA editing in metazoans.CELL REPORTS,42(2).
MLA	Zhang, P,et al."On the origin and evolution of RNA editing in metazoans".CELL REPORTS 42.2(2023).

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