A global catalog of whole-genome diversity from 233 primate species

	A global catalog of whole-genome diversity from 233 primate species
	Kuderna, LFK; Gao, H; Janiak, MC; Kuhlwilm, M; Orkin, JD; Bataillon, T; Manu, S; Valenzuela, A; Bergman, J; Rousselle, M; Silva, FE; Agueda, L; Blanc, J; Gut, M; de Vries, D; Goodhead, I; Harris, RA; Raveendran, M; Jensen, A; Chuma, IS; Horvath, JE; Hvilsom, C; Juan, DV; Frandsen, P; Schraiber, JG; de Melo, FR; Bertuol, F; Byrne, H; Sampaio, I; Farias, I; Valsecchi, J; Messias, M; da Silva, MNF; Trivedi, M; Rossi, R; Hrbek, T; Andriaholinirina, N; Rabarivola, CJ; Zaramody, A; Jolly, CJ; Phillips-Conroy, J; Wilkerson, G; Abee, C; Simmons, JH; Fernandez-Duque, E; Kanthaswamy, S; Shiferaw, F; Wu, DD; Zhou, L; Shao, Y; Zhang, GJ; Keyyu, JD; Knauf, S; Le, MD; Lizano, E; Merker, S; Navarro, A; Nadler, T; Khor, CC; Lee, J; Tan, PT; Lim, WK; Kitchener, AC; Zinner, D; Gut, I; Melin, AD; Guschanski, K; Schierup, MH; Beck, RMD; Umapathy, G; Roos, C; Boubli, JP; Rogers, J; Farh, KKH; Bonet, TM
	2023
发表期刊	SCIENCE
ISSN	0036-8075
卷号	380 期号:6648 页码:906-912
摘要	The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact of genomic diversity on fundamental biological processes. Analysis of that diversity provides insight into long-standing questions in evolutionary and conservation biology and is urgent given severe threats these species are facing. Here, we present high-coverage wholegenome data from 233 primate species representing 86% of genera and all 16 families. This dataset was used, together with fossil calibration, to create a nuclear DNA phylogeny and to reassess evolutionary divergence times among primate clades. We found within-species genetic diversity across families and geographic regions to be associated with climate and sociality, but not with extinction risk. Furthermore, mutation rates differ across species, potentially influenced by effective population sizes. Lastly, we identified extensive recurrence of missense mutations previously thought to be human specific. This study will open a wide range of research avenues for future primate genomic research.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14061
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Kuderna, LFK,Gao, H,Janiak, MC,et al. A global catalog of whole-genome diversity from 233 primate species[J]. SCIENCE,2023,380(6648):906-912.
APA	Kuderna, LFK.,Gao, H.,Janiak, MC.,Kuhlwilm, M.,Orkin, JD.,...&Bonet, TM.(2023).A global catalog of whole-genome diversity from 233 primate species.SCIENCE,380(6648),906-912.
MLA	Kuderna, LFK,et al."A global catalog of whole-genome diversity from 233 primate species".SCIENCE 380.6648(2023):906-912.

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2024061442.pdf（3340KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文