Inhibiting cardiac autophagy suppresses Zika virus replication

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	Inhibiting cardiac autophagy suppresses Zika virus replication
	Ma, X; Jia, YN; Yuan, J; Tang, QJ; Gao, WC; Zhou, GF; Yang, RH; Pang, W; Zheng, CB
	2023
发表期刊	JOURNAL OF MEDICAL VIROLOGY
ISSN	0146-6615
卷号	95 期号:2
摘要	Zika Virus (ZIKV) infection is a global threat. Other than the congenital neurological disorders it causes, ZIKV infection has been reported to induce cardiac complications. However, the precise treatment plans are unclear. Thus, illustrating the pathogenic mechanism of ZIKV in the heart is critical to providing effective prevention and treatment of ZIKV infection. The mechanism of autophagy has been reported recently in Dengue virus infection. Whether or not autophagy participates in ZIKV infection and its role remains unrevealed. This study successfully established the in vitro cardiomyocytes and in vivo mouse models of ZIKV infection to investigate the involvement of autophagy in ZIKV infection. The results showed that ZIKV infection is both time and gradient-dependent. The key autophagy protein, LC3B, increased remarkably after ZIKV infection. Meanwhile, autophagic flux was detected by immunofluorescence. Applying autophagy inhibitors decreased the LC3B levels. Furthermore, the number of viral copies was quantified to evaluate the influence of autophagy during infection. We found that autophagy was actively involved in the ZIKV infection and the inhibition of autophagy could effectively reduce the viral copies, suggesting a potential intervention strategy for reducing ZIKV infection and the undesired complications caused by ZIKV.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14100
专题	其他
推荐引用方式 GB/T 7714	Ma, X,Jia, YN,Yuan, J,et al. Inhibiting cardiac autophagy suppresses Zika virus replication[J]. JOURNAL OF MEDICAL VIROLOGY,2023,95(2).
APA	Ma, X.,Jia, YN.,Yuan, J.,Tang, QJ.,Gao, WC.,...&Zheng, CB.(2023).Inhibiting cardiac autophagy suppresses Zika virus replication.JOURNAL OF MEDICAL VIROLOGY,95(2).
MLA	Ma, X,et al."Inhibiting cardiac autophagy suppresses Zika virus replication".JOURNAL OF MEDICAL VIROLOGY 95.2(2023).

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