SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1

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	SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1
	Qiu, T; Hou, L; Zhao, LN; Wang, XY; Zhou, ZM; Yang, CY; Zhang, HF; Jiang, DW; Jiao, BW; Chen, CS
	2023
发表期刊	JOURNAL OF BIOLOGICAL CHEMISTRY
卷号	299 期号:11
摘要	Breast cancer stem cells are mainly responsible for poor prognosis, especially in triple-negative breast cancer (TNBC). In a previous study, we demonstrated that e-Sarcoglycan (SGCE), a type I single-transmembrane protein, is a potential oncogene that promotes TNBC stemness by stabilizing EGFR. Here, we further found that SGCE depletion reduces breast cancer stem cells, partially through inhibiting the transcription of FGF-BP1, a secreted oncoprotein. Mechanistically, we demonstrate that SGCE could interact with the specific protein 1 transcription factor and translocate into the nucleus, which leads to an increase in the transcription of FGF-BP1, and the secreted FBF-BP1 activates FGF-FGFR signaling to promote cancer cell stemness. The novel SGCE-Sp1-FGF-BP1 axis provides novel potential candidate diagnostic markers and therapeutic targets for TNBC.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14190
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Qiu, T,Hou, L,Zhao, LN,et al. SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2023,299(11).
APA	Qiu, T.,Hou, L.,Zhao, LN.,Wang, XY.,Zhou, ZM.,...&Chen, CS.(2023).SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1.JOURNAL OF BIOLOGICAL CHEMISTRY,299(11).
MLA	Qiu, T,et al."SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1".JOURNAL OF BIOLOGICAL CHEMISTRY 299.11(2023).

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