Toxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducing ROS-mediated apoptosis and DNA damage

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Toxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducing ROS-mediated apoptosis and DNA damage
	Wu, TY; Liu, WJ; Chen, H; Hou, L; Ren, WL; Zhang, LL; Hu, JH; Chen, HJ; Chen, CS
	2024
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	14 期号:1
摘要	Triple-negative breast cancer (TNBC) is regarded as the deadliest subtype of breast cancer because of its high heterogeneity, aggressiveness, and limited treatment options. Toxoflavin has been reported to possess antitumor activity. In this study, a series of toxoflavin analogs were synthesized, among which D43 displayed a significant dose-dependent inhibitory effect on the proliferation of TNBC cells (MDA-MB-231 and HCC1806). Additionally, D43 inhibited DNA synthesis in TNBC cells, leading to cell cycle arrest at the G2/M phase. Furthermore, D43 consistently promoted intracellular ROS generation, induced DNA damage, and resulted in apoptosis in TNBC cells. These effects could be reversed by N-acetylcysteine. Moreover, D43 significantly inhibited the growth of breast cancer patient-derived organoids and xenografts with a favorable biosafety profile. In conclusion, D43 is a potent anticancer agent that elicits significant antiproliferation, oxidative stress, apoptosis, and DNA damage effects in TNBC cells, and D43 holds promise as a potential candidate for the treatment of TNBC.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14227
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Wu, TY,Liu, WJ,Chen, H,et al. Toxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducing ROS-mediated apoptosis and DNA damage[J]. SCIENTIFIC REPORTS,2024,14(1).
APA	Wu, TY.,Liu, WJ.,Chen, H.,Hou, L.,Ren, WL.,...&Chen, CS.(2024).Toxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducing ROS-mediated apoptosis and DNA damage.SCIENTIFIC REPORTS,14(1).
MLA	Wu, TY,et al."Toxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducing ROS-mediated apoptosis and DNA damage".SCIENTIFIC REPORTS 14.1(2024).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2024073119.pdf（7543KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文