The underappreciated diversity of bile acid modifications

KIZ OpenIR

	The underappreciated diversity of bile acid modifications
	Mohanty, I; Mannochio-Russo, H; Schweer, JV; Abiead, YE; Bittremieux, W; Xing, SP; Schmid, R; Zuffa, S; Vasquez, F; Muti, VB; Zemlin, J; Tovar-Herrera, OE; Moraïs, S; Desai, D; Amin, S; Koo, I; Turck, CW; Mizrahi, I; Kris-Etherton, PM; Petersen, KS; Fleming, JA; Huan, T; Patterson, AD; Siegel, D; Hagey, LR; Wang, MX; Aron, AT; Dorrestein, PC
	2024
发表期刊	CELL
ISSN	0092-8674
卷号	187 期号:7
摘要	The repertoire of modifications to bile acids and related steroidal lipids by host and microbial metabolism remains incompletely characterized. To address this knowledge gap, we created a reusable resource of tandem mass spectrometry (MS/MS) spectra by filtering 1.2 billion publicly available MS/MS spectra for bileacid -selective ion patterns. Thousands of modifications are distributed throughout animal and human bodies as well as microbial cultures. We employed this MS/MS library to identify polyamine bile amidates, prevalent in carnivores. They are present in humans, and their levels alter with a diet change from a Mediterranean to a typical American diet. This work highlights the existence of many more bile acid modifications than previously recognized and the value of leveraging public large-scale untargeted metabolomics data to discover metabolites. The availability of a modification -centric bile acid MS/MS library will inform future studies investigating bile acid roles in health and disease.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14418
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Mohanty, I,Mannochio-Russo, H,Schweer, JV,et al. The underappreciated diversity of bile acid modifications[J]. CELL,2024,187(7).
APA	Mohanty, I.,Mannochio-Russo, H.,Schweer, JV.,Abiead, YE.,Bittremieux, W.,...&Dorrestein, PC.(2024).The underappreciated diversity of bile acid modifications.CELL,187(7).
MLA	Mohanty, I,et al."The underappreciated diversity of bile acid modifications".CELL 187.7(2024).

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2024080127.pdf（15752KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文