Antimalarial activity of cecropin antimicrobial peptides derived from Anopheles mosquitoes

	Antimalarial activity of cecropin antimicrobial peptides derived from Anopheles mosquitoes
	Lou, JC; Zhang, DY; Wu, JY; Zhu, GD; Zhang, MH; Tang, JX; Fang, YQ; He, XQ; Cao, J
	2024
发表期刊	ANTIMICROB AGENTS CH
ISSN	0066-4804
卷号	68 期号:7
摘要	The emergence of clinically drug-resistant malaria parasites requires the urgent development of new drugs. Mosquitoes are vectors of multiple pathogens and have developed resistance mechanisms against them, which often involve antimicrobial peptides (AMPs). An-cecB is an AMP of the malaria-transmitting mosquito genus Anopheles, and we herein report its antimalarial activity against Plasmodium falciparum 3D7, the artemisinin-resistant strain 803, and the chloroquine-resistant strain Dd2 in vitro. We also demonstrate its anti-parasite activity in vivo, using the rodent malaria parasite Plasmodium berghei (ANKA). We show that An-cecB displays potent antimalarial activity and that its mechanism of action may occur through direct killing of the parasite or through interaction with infected red blood cell membranes. Unfortunately, An-cecB was found to be cytotoxic to mammalian cells and had poor antimalarial activity in vivo. However, its truncated peptide An-cecB-1 retained most of its antimalarial activity and avoided its cytotoxicity in vitro. An-cecB-1 also showed better antimalarial activity in vivo. Mosquito-derived AMPs may provide new ideas for the development of antimalarial drugs against drug-resistant parasites, and An-cecB has potential use as a template for antimalarial peptides.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14595
专题	科研部门_天然药物功能蛋白质学科组（赖仞）
推荐引用方式 GB/T 7714	Lou, JC,Zhang, DY,Wu, JY,et al. Antimalarial activity of cecropin antimicrobial peptides derived from Anopheles mosquitoes[J]. ANTIMICROB AGENTS CH,2024,68(7).
APA	Lou, JC.,Zhang, DY.,Wu, JY.,Zhu, GD.,Zhang, MH.,...&Cao, J.(2024).Antimalarial activity of cecropin antimicrobial peptides derived from Anopheles mosquitoes.ANTIMICROB AGENTS CH,68(7).
MLA	Lou, JC,et al."Antimalarial activity of cecropin antimicrobial peptides derived from Anopheles mosquitoes".ANTIMICROB AGENTS CH 68.7(2024).

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