| Kallikrein inhibitor derived from immunoglobulin heavy chain junction region possesses anti-thromboinflammation potential |
| Yang, J; Li, ZY; Deng, XY; Li, MR; Li, B ; Thuku, RC; Chen, Q; Sun, X; Lu, QM; Fang, MQ
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| 2024
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| 发表期刊 | PHARMACOL RES
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| ISSN | 1043-6618
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| 卷号 | 209 |
| 摘要 | Influenza vaccination is associated with a reduced incidence of cardiovascular events, cardiovascular death, and all-cause mortality. However, the functional role of the associated immunoglobulin remains unclear. This study identified a specific influenza-related immunoglobulin heavy chain junction region sequence (Ser-Leu-Gly-AlaSer-Asp, SD6) that inhibited plasma kallikrein (PKa) activity to resist thromboinflammatory responses and stroke injury. PKa is considered an attractive therapeutic target for alleviating the complications of thrombophiliainduced inflammation. In vitro, SD6 prolonged plasma recalcification and activated partial thromboplastin time, with no effects on bleeding risk-related prothrombin time, indicating selective inhibition of the intrinsic coagulation pathway. Correspondingly, at doses ranging from 0.25 to 4 mg/kg, SD6 attenuated arterial and cortical venous thrombosis in FeCl3-induced and photochemically induced mice, without impacting hemorrhage risk, and further mitigated cerebral inflammatory injury in a mouse model of transient middle cerebral artery occlusion ischemic stroke. These findings suggest that SD6 may serve as a potential therapeutic agent for the treatment of thromboinflammatory conditions. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14602
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| 专题 | 科研部门_天然药物功能蛋白质学科组（赖仞）
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推荐引用方式
GB/T 7714 |
Yang, J,Li, ZY,Deng, XY,et al. Kallikrein inhibitor derived from immunoglobulin heavy chain junction region possesses anti-thromboinflammation potential[J]. PHARMACOL RES,2024,209.
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| APA |
Yang, J.,Li, ZY.,Deng, XY.,Li, MR.,Li, B.,...&Fang, MQ.(2024).Kallikrein inhibitor derived from immunoglobulin heavy chain junction region possesses anti-thromboinflammation potential.PHARMACOL RES,209.
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| MLA |
Yang, J,et al."Kallikrein inhibitor derived from immunoglobulin heavy chain junction region possesses anti-thromboinflammation potential".PHARMACOL RES 209(2024).
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