Dual Role of Lysosome in Cancer Development and Progression

KIZ OpenIR > 科研部门 > 分子人类学（孔庆鹏）

	Dual Role of Lysosome in Cancer Development and Progression
	Chen, XQ; Yang, Q; Chen, WM; Chen, ZW; Guo, GH; Zhang, X; Sun, XM; Shen, T; Xiao, FH; Li, YF
	2024
发表期刊	FRONT BIOSCI-LANDMRK
ISSN	2768-6701
卷号	29 期号:11
摘要	Lysosomes are essential intracellular catabolic organelles that contain digestive enzymes involved in the degradation and recycle of damaged proteins, organelles, etc. Thus, they play an important role in various biological processes, including autophagy regulation, ion homeostasis, cell death, cell senescence. A myriad of studies has shown that the dysfunction of lysosome is implicated in human aging and various age-related diseases, including cancer. However, what is noteworthy is that the modulation of lysosome-based signaling and degradation has both the cancer-suppressive and cancer-promotive functions in diverse cancers depending on stage, biology, or tumor microenvironment. This dual role limits their application as targets in cancer therapy. In this review, we provide an overview of lysosome and autophagy-lysosomal pathway and outline their critical roles in many cellular processes, including cell death. We highlight the different functions of autophagy-lysosomal pathway in cancer development and progression, underscoring its potential as a target for effective cancer therapies.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14614
专题	科研部门_分子人类学（孔庆鹏）
推荐引用方式 GB/T 7714	Chen, XQ,Yang, Q,Chen, WM,et al. Dual Role of Lysosome in Cancer Development and Progression[J]. FRONT BIOSCI-LANDMRK,2024,29(11).
APA	Chen, XQ.,Yang, Q.,Chen, WM.,Chen, ZW.,Guo, GH.,...&Li, YF.(2024).Dual Role of Lysosome in Cancer Development and Progression.FRONT BIOSCI-LANDMRK,29(11).
MLA	Chen, XQ,et al."Dual Role of Lysosome in Cancer Development and Progression".FRONT BIOSCI-LANDMRK 29.11(2024).

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KQP2025041001.pdf（1111KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文