The mitochondrial long non-coding RNA lncMtloop regulates mitochondrial transcription and suppresses Alzheimer's disease

	The mitochondrial long non-coding RNA lncMtloop regulates mitochondrial transcription and suppresses Alzheimer's disease
	Xiong, WD; Xu, KY; Sun, JKL; Liu, SL; Zhao, BZ; Shi, J; Herrup, K; Chow, HM; Lu, L; Li, JL
	2024
发表期刊	EMBO J
ISSN	0261-4189
卷号	43 期号:23 页码:6001-6031
摘要	Maintaining mitochondrial homeostasis is crucial for cell survival and organismal health, as evidenced by the links between mitochondrial dysfunction and various diseases, including Alzheimer's disease (AD). Here, we report that lncMtDloop, a non-coding RNA of unknown function encoded within the D-loop region of the mitochondrial genome, maintains mitochondrial RNA levels and function with age. lncMtDloop expression is decreased in the brains of both human AD patients and 3xTg AD mouse models. Furthermore, lncMtDloop binds to mitochondrial transcription factor A (TFAM), facilitates TFAM recruitment to mtDNA promoters, and increases mitochondrial transcription. To allow lncMtDloop transport into mitochondria via the PNPASE-dependent trafficking pathway, we fused the 3'UTR localization sequence of mitochondrial ribosomal protein S12 (MRPS12) to its terminal end, generating a specified stem-loop structure. Introducing this allotropic lncMtDloop into AD model mice significantly improved mitochondrial function and morphology, and ameliorated AD-like pathology and behavioral deficits of AD model mice. Taken together, these data provide insights into lncMtDloop as a regulator of mitochondrial transcription and its contribution to Alzheimer's pathogenesis
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14684
专题	科研部门_表观遗传与神经退行性疾病（李家立）
推荐引用方式 GB/T 7714	Xiong, WD,Xu, KY,Sun, JKL,et al. The mitochondrial long non-coding RNA lncMtloop regulates mitochondrial transcription and suppresses Alzheimer's disease[J]. EMBO J,2024,43(23):6001-6031.
APA	Xiong, WD.,Xu, KY.,Sun, JKL.,Liu, SL.,Zhao, BZ.,...&Li, JL.(2024).The mitochondrial long non-coding RNA lncMtloop regulates mitochondrial transcription and suppresses Alzheimer's disease.EMBO J,43(23),6001-6031.
MLA	Xiong, WD,et al."The mitochondrial long non-coding RNA lncMtloop regulates mitochondrial transcription and suppresses Alzheimer's disease".EMBO J 43.23(2024):6001-6031.

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