Microbial infection instigates tau-related pathology in Alzheimer's disease via activating neuroimmune cGAS-STING pathway

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	Microbial infection instigates tau-related pathology in Alzheimer's disease via activating neuroimmune cGAS-STING pathway
	Yan, XX; Wang, ER; Zhao, M; Ma, GQ; Xu, XX; Zhao, JB; Li, XH; Zeng, JX; Ma, XL
	2025
发表期刊	NEUROSCIENCE
ISSN	0306-4522
卷号	572 页码:122-133
摘要	Microbial infection, the strong trigger to directly induce inflammation in brain, is long considered a risk factor of Alzheimer's disease (AD), but how these infections contribute to neurodegeneration remains underexplored. To examine the effect of herpes simplex virus type 1 (HSV-1) infection on tauopathy in local hippocampus of P301S mice, we utilized a modified HSV-1 strain (mHSV-1) potentially relevant to AD, we found that its infection promotes tau-related pathology in part via activating neuroimmune cGAS-STING pathway in the tau mouse model. Specifically, Sting ablation causes the detectable improvement of neuronal dysfunction and loss in P301S mice, which is causally linked to lowered proinflammatory status in the brain. Administration of STING inhibitor H-151 alleviates neuroinflammation and tau-related pathology in P301S mice. These results jointly suggest that herpesviral infection, as the vital environmental risk factor, could induce tau-related pathology in AD pathogenesis partially via neuroinflammatory cGAS-STING pathway.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14692
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Yan, XX,Wang, ER,Zhao, M,et al. Microbial infection instigates tau-related pathology in Alzheimer's disease via activating neuroimmune cGAS-STING pathway[J]. NEUROSCIENCE,2025,572:122-133.
APA	Yan, XX.,Wang, ER.,Zhao, M.,Ma, GQ.,Xu, XX.,...&Ma, XL.(2025).Microbial infection instigates tau-related pathology in Alzheimer's disease via activating neuroimmune cGAS-STING pathway.NEUROSCIENCE,572,122-133.
MLA	Yan, XX,et al."Microbial infection instigates tau-related pathology in Alzheimer's disease via activating neuroimmune cGAS-STING pathway".NEUROSCIENCE 572(2025):122-133.

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ZJX2025042103.pdf（8290KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文