High-quality sika deer omics data and integrative analysis reveal genic and cellular regulation of antler regeneration

KIZ OpenIR

	High-quality sika deer omics data and integrative analysis reveal genic and cellular regulation of antler regeneration
	Li, ZH; Xu, ZY; Zhu, L; Qin, T; Ma, JR; Feng, ZY; Yue, HS; Guan, Q; Zhou, BT; Han, G; Zhang, GK; Li, CY; Jia, SJ; Qiu, Q; Hao, DJ; Wang, Y; Wang, W
	2025
发表期刊	GENOME RESEARCH
ISSN	1088-9051
卷号	35 期号:1 页码:188-201
摘要	The antler is the only organ that can fully regenerate annually in mammals. However, the regulatory pattern and mechanism of gene expression and cell differentiation during this process remain largely unknown. Here, we obtain comprehensive assembly and gene annotation of the sika deer (Cervus nippon) genome. We construct, together with large-scale chromatin accessibility and gene expression data, gene regulatory networks involved in antler regeneration, identifying four transcription factors, MYC, KLF4, NFE2L2, and JDP2, with high regulatory activity across the whole regeneration process. Comparative studies and luciferase reporter assay suggest the MYC expression driven by a cervid-specific regulatory element might be important for antler regenerative ability. We further develop a model called combinatorial TF Oriented Program (cTOP), which integrates single-cell data with bulk regulatory networks and find PRDM1, FOSL1, BACH1, and NFATC1 as potential pivotal factors in antler stem cell activation and osteogenic differentiation. Additionally, we uncover interactions within and between cell programs and pathways during the regeneration process. These findings provide insights into the gene and cell regulatory mechanisms of antler regeneration, particularly in stem cell activation and differentiation.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14728
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Li, ZH,Xu, ZY,Zhu, L,et al. High-quality sika deer omics data and integrative analysis reveal genic and cellular regulation of antler regeneration[J]. GENOME RESEARCH,2025,35(1):188-201.
APA	Li, ZH.,Xu, ZY.,Zhu, L.,Qin, T.,Ma, JR.,...&Wang, W.(2025).High-quality sika deer omics data and integrative analysis reveal genic and cellular regulation of antler regeneration.GENOME RESEARCH,35(1),188-201.
MLA	Li, ZH,et al."High-quality sika deer omics data and integrative analysis reveal genic and cellular regulation of antler regeneration".GENOME RESEARCH 35.1(2025):188-201.

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WW2025040705.pdf（8419KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文