High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to thrombosis

	High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to thrombosis
	Huang, XS; Tang, XP; He, QY; Adisu, D; Cao, KX; Gao, JA; Xu, QY; Cheng, RM; Lu, QM; Chen, YF; Yang, M; Du, Y; Mwangi, J; Ni, HY; Lai, R; Ni, HY; Lai, R
	2025
发表期刊	Cell Rep. Med.
ISSN	2666-3791
卷号	6 期号:8
摘要	Circulating palmitic acid (PA) is generally considered to be provided from diets and endogenous synthesis and is adversely correlated with cardiovascular disease (CVD). It is unknown, however, if gut microbiota modulates circulating PA and potentiates CVD risk. Here we demonstrate that, in CVD patients, elevated circulating PA is accompanied with hypercoagulability and high gut Bacteroides thetaiotaomicron (BT) abundance. PA promotes coagulation by inhibiting a major endogenous anticoagulant activated protein C (APC) and enhancing platelet activation. Importantly, BT is capable of synthesizing PA, and high-fat diet amplifies gut BT colonization. Our findings show that BT transplantation elevates plasma PA and triggers hypercoagulation without alternating host lipogenesis. Hesperidin, adietary flavonoid, inhibits PA-APC interaction to prevent hypercoagulation induced by PA or BT transplantation. Collectively, we reveal the promotion of high-fat diet on gut BT colonization that elevates circulating PA and CVD risk, suggesting an approach controlling CVD by targeting PA and BT.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14841
专题	科研部门_天然药物功能蛋白质学科组（赖仞）
推荐引用方式 GB/T 7714	Huang, XS,Tang, XP,He, QY,et al. High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to thrombosis[J]. Cell Rep. Med.,2025,6(8).
APA	Huang, XS.,Tang, XP.,He, QY.,Adisu, D.,Cao, KX.,...&Lai, R.(2025).High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to thrombosis.Cell Rep. Med.,6(8).
MLA	Huang, XS,et al."High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to thrombosis".Cell Rep. Med. 6.8(2025).

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