Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery

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	Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery
	Zhang, CY; Li, M; Sun, P; Hui, L; Gao, Y; Yang, JZ; Zhang, N; Feng, XY; Wu, Y; Guo, L; Yuan, J; Jiang, HY; Cheng, YQ; Ma, SM; Gong, Q; Sun, YY; Li, Y; Qu, N; Yin, XY; Wang, L; Yang, YF; Wang, CS; Lv, LX; Zhou, DS; Li, XX; Chen, XG; Zhang, C; Chen, J; Song, XQ; Tang, JS; Cai, J; Fan, WX; Tang, W; Tang, WX; Li, WQ; Tang, X; Zhang, XX; Lu, Y; Yao, YG; Wang, C; So, HC; Iwata, N; Ikeda, M; Saito, T; Liu, ZC; Xu, SH; Yue, WH; Fang, YR; Zhu, F; Xiao, X; Li, M
	2026
发表期刊	Nat. Neurosci.
ISSN	1097-6256
卷号	29 期号:2
摘要	Genome-wide association studies (GWASs) of bipolar disorder (BD) have predominantly included individuals of European (EUR) ancestry, underrepresenting non-EUR populations and limiting insight into disease mechanisms. Here we performed a GWAS of BD in Han Chinese individuals (5,164 cases and 13,460 controls) and conducted comparative and integrative analyses with independent East Asian (EAS, 4,479 cases and 75,725 controls) and EUR (59,287 cases and 781,022 controls) cohorts from the PGC4 GWAS. Our GWAS in EAS ancestry identified two genome-wide significant risk loci, including variants at the major histocompatibility complex (MHC) class II region. Incorporating EAS data into trans-ancestry GWAS revealed 93 significant loci (23 novel). Heritability enrichment analyses implicated a variety of neuronal cell types. Multidimensional post-GWAS prioritization identified 39 high-confidence risk genes, of which 15 were differentially expressed in the brains of patients with BD, 12 modulated BD-relevant behaviors in mice and 18 are pharmacologically tractable. This work advances understanding of the biological underpinnings of BD and provides direction for future research in underrepresented populations.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14922
专题	科研部门_转化基因组（李明）
推荐引用方式 GB/T 7714	Zhang, CY,Li, M,Sun, P,et al. Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery[J]. Nat. Neurosci.,2026,29(2).
APA	Zhang, CY.,Li, M.,Sun, P.,Hui, L.,Gao, Y.,...&Li, M.(2026).Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery.Nat. Neurosci.,29(2).
MLA	Zhang, CY,et al."Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery".Nat. Neurosci. 29.2(2026).

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