The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project

	The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project
	Fang, LZ; Teng, JY; Lin, Q; Bai, ZH; Liu, SL; Guan, DL; Li, BJ; Gao, YH; Hou, YL; Gong, M; Pan, ZY; Yu, Y; Clark, EL; Smith, J; Rawlik, K; Xiang, RD; Chamberlain, AJ; Goddard, ME; Littlejohn, M; Larson, G; MacHugh, DE; O'Grady, JF; Sorensen, P; Sahana, G; Lund, MS; Jiang, ZH; Pan, XC; Gong, WT; Zhang, HH; He, X; Zhang, YB; Gao, N; He, J; Yi, GQ; Liu, YW; Tang, ZL; Zhao, PJ; Zhou, Y; Fu, LL; Wang, X; Hao, D; Liu, L; Chen, SQ; Young, RS; Shen, X; Xia, C; Cheng, H; Ma, L; Cole, JB; Baldwin, RL; Li, CJ; Guan, LL; Zhao, X; Ibeagha-Awemu, EM; Luo, YL; Lin, L; Canela-Xandri, O; Derks, MFL; Crooijmans, RPMA; Gòdia, M; Madsen, O; Groenen, MAM; Koltes, JE; Tuggle, CK; McCarthy, FM; Rocha, D; Giuffra, E; Amills, M; Clop, A; Ballester, M; Tosser-Klopp, G; Li, J; Fang, C; Fang, M; Wang, QS; Hou, ZC; Wang, Q; Zhao, FP; Jiang, L; Zhao, GP; Zhou, ZK; Zhou, R; Liu, HH; Deng, J; Jin, L; Li, MZ; Mo, DL; Liu, XH; Chen, YS; Yuan, XL; Li, J; Zhao, SH; Zhang, Y; Ding, XD; Sun, DX; Sun, HZ; Li, C; Wang, Y; Jiang, Y; Wu, DD; Wang, WW; Fan, XZ; Zhang, Q; Li, K; Zhang, H; Yang, N; Hu, XX; Huang, W; Song, JZ; Wu, Y; Yang, J; Wu, WW; Kasper, C; Liu, XF; Yu, XF; Cui, LL; Zhou, X; Kim, S; Li, W; Im, HK; Buckler, ES; Ren, B; Schatz, MC; Li, JJ; Palmer, AA; Frantz, L; Zhou, HJ; Zhang, Z; Liu, GE; Rosen, BD; Bhowmik, N; Lunney, J; Liu, WS; Van Tassell, CP
	2025
发表期刊	Nat. Genet.
ISSN	1061-4036
卷号	57 期号:4 页码:786-796
摘要	Genetic mutation and drift, coupled with natural and human-mediated selection and migration, have produced a wide variety of genotypes and phenotypes in farmed animals. We here introduce the Farm Animal Genotype-Tissue Expression (FarmGTEx) Project, which aims to elucidate the genetic determinants of gene expression across 16 terrestrial and aquatic domestic species under diverse biological and environmental contexts. For each species, we aim to collect multiomics data, particularly genomics and transcriptomics, from 50 tissues of 1,000 healthy adults and 200 additional animals representing a specific context. This Perspective provides an overview of the priorities of FarmGTEx and advocates for coordinated strategies of data analysis and resource-sharing initiatives. FarmGTEx aims to serve as a platform for investigating context-specific regulatory effects, which will deepen our understanding of molecular mechanisms underlying complex phenotypes. The knowledge and insights provided by FarmGTEx will contribute to improving sustainable agriculture-based food systems, comparative biology and eventual human biomedicine. The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14940
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Fang, LZ,Teng, JY,Lin, Q,et al. The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project[J]. Nat. Genet.,2025,57(4):786-796.
APA	Fang, LZ.,Teng, JY.,Lin, Q.,Bai, ZH.,Liu, SL.,...&Van Tassell, CP.(2025).The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project.Nat. Genet.,57(4),786-796.
MLA	Fang, LZ,et al."The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project".Nat. Genet. 57.4(2025):786-796.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2026070725.pdf（1878KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文