Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques

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	Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques
	Hao, YM; Yu, BB; Qin, MZ; Qin, T; Wang, JH; Wei, YT; Zhao, CX; Xing, YW; Yuan, Y; Xue, TF; Xue, BR; Zhang, YL; Huang, HD; Yu, XM; Ji, YC; Qiu, MH; Zhou, YF; Xia, B; Ma, T; Li, SY; Wu, HN; Gao, X; Yang, YJ; Guo, LL; Zhang, YF; Wang, ZG; Sun, HL; Gao, XL; Huang, ZJ; Lv, LB; Wu, DD; Li, ZP; Yao, YG; Wang, W; Luo, ZJ; Qiu, Q; Huang, JH
	2025
发表期刊	Nature Aging
卷号	5 期号:9 页码:1790-1809
摘要	Antler blastema progenitor cells (ABPCs) are a distinct population of skeletal mesenchymal stem cells found in regenerating deer antlers, with strong stemness and renewal capacity in vitro. Stem cell-derived extracellular vesicles (EVs) are emerging as potential therapeutic candidates that can mediate donor cells' beneficial effects. Here, we tested the effects of ABPC-derived EVs (EVsABPC) on aging in mice and rhesus macaques (Macaca mulatta). We identified a variety of unique factors in EVsABPC and showed that in vitro, EVsABPC attenuated phenotypes of senescence in bone marrow stem cells. In aged mice and macaques, EVsABPC substantially increased femoral bone mineral density. Further, intravenous EVsABPC improved physical performance, enhanced cognitive function and reduced systemic inflammation in aged mice, while reversing epigenetic age by over 3 months. In macaques, EVABPC treatment was also neuroprotective, reduced inflammation, improved locomotor function and reduced epigenetic age by over 2 years. Our findings position ABPCs as an emerging and practical source of EVs with translational value for healthy aging interventions.
收录类别	SCIE
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/15034
专题	科研部门_鸟类学（杨晓君）
推荐引用方式 GB/T 7714	Hao, YM,Yu, BB,Qin, MZ,et al. Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques[J]. Nature Aging,2025,5(9):1790-1809.
APA	Hao, YM.,Yu, BB.,Qin, MZ.,Qin, T.,Wang, JH.,...&Huang, JH.(2025).Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques.Nature Aging,5(9),1790-1809.
MLA	Hao, YM,et al."Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques".Nature Aging 5.9(2025):1790-1809.

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