Evolutionary characteristics of exons expressed at different abundance levels in mammals

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	Evolutionary characteristics of exons expressed at different abundance levels in mammals
	Yu HJ 1; Fang L 2; Li X 3; Zhang XY 1; Ye J 2; Li J 1; Hu WH 1; Zheng BR 1; Xiao CJ*1; cjxiao@public.km.yn.cn
	2009
发表期刊	CHINESE SCIENCE BULLETIN
ISSN	1001-6538
卷号	54 期号:19 页码:3546-3554
合作性质	其它
摘要	With comparative genomics approaches, we evaluated the evolutionary characteristics of conservation of exons which are expressed abundantly, moderately or lowly in mammals. Using non-coding regions and pseudogenes as controls, sequence identity, phastCons and Ka/Ks analyses were carried out and our results showed that as the exons of high abundance are highly conserved, the minor and low exons also showed conservative characteristics in evolution. Our findings suggested that the exons with less abundance which constitute a large proportion of distinct species in transcriptome of organisms are under functional constraint and might play certain roles in enriching biological complexity in the evolution of organisms.
关键词	Exon Evolution Sequence Identity Phastcon Ka/ks
学科领域	Multidisciplinary Sciences
资助者	Supported by the National Natural Science Foundation of China (Grant Nos. 30871342, J073652, 30660076 and 30740420553), Western Light Program and Yunnan Province Young Scientist Project (Grant No. 2008PY025), Undergraduate Science Novelty Training Project ; Supported by the National Natural Science Foundation of China (Grant Nos. 30871342, J073652, 30660076 and 30740420553), Western Light Program and Yunnan Province Young Scientist Project (Grant No. 2008PY025), Undergraduate Science Novelty Training Project ; Supported by the National Natural Science Foundation of China (Grant Nos. 30871342, J073652, 30660076 and 30740420553), Western Light Program and Yunnan Province Young Scientist Project (Grant No. 2008PY025), Undergraduate Science Novelty Training Project ; Supported by the National Natural Science Foundation of China (Grant Nos. 30871342, J073652, 30660076 and 30740420553), Western Light Program and Yunnan Province Young Scientist Project (Grant No. 2008PY025), Undergraduate Science Novelty Training Project
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收录类别	SCI
语种	英语
资助者	Supported by the National Natural Science Foundation of China (Grant Nos. 30871342, J073652, 30660076 and 30740420553), Western Light Program and Yunnan Province Young Scientist Project (Grant No. 2008PY025), Undergraduate Science Novelty Training Project ; Supported by the National Natural Science Foundation of China (Grant Nos. 30871342, J073652, 30660076 and 30740420553), Western Light Program and Yunnan Province Young Scientist Project (Grant No. 2008PY025), Undergraduate Science Novelty Training Project ; Supported by the National Natural Science Foundation of China (Grant Nos. 30871342, J073652, 30660076 and 30740420553), Western Light Program and Yunnan Province Young Scientist Project (Grant No. 2008PY025), Undergraduate Science Novelty Training Project ; Supported by the National Natural Science Foundation of China (Grant Nos. 30871342, J073652, 30660076 and 30740420553), Western Light Program and Yunnan Province Young Scientist Project (Grant No. 2008PY025), Undergraduate Science Novelty Training Project
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4849
专题	基因起源组遗传资源与进化国家重点实验室
通讯作者	cjxiao@public.km.yn.cn
作者单位	1.Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center of Yunnan University, Kunming 650091, China 2.Beijing Genomics Institute at Shenzhen, Shenzhen 518083, China 3.CAS-Max Planck Junior Research Group and State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Yu HJ,Fang L,Li X,et al. Evolutionary characteristics of exons expressed at different abundance levels in mammals[J]. CHINESE SCIENCE BULLETIN,2009,54(19):3546-3554.
APA	Yu HJ.,Fang L.,Li X.,Zhang XY.,Ye J.,...&cjxiao@public.km.yn.cn.(2009).Evolutionary characteristics of exons expressed at different abundance levels in mammals.CHINESE SCIENCE BULLETIN,54(19),3546-3554.
MLA	Yu HJ,et al."Evolutionary characteristics of exons expressed at different abundance levels in mammals".CHINESE SCIENCE BULLETIN 54.19(2009):3546-3554.

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