Is there a close relationship between synonymous codon bias and codon-anticodon binding strength in human genes?

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	Is there a close relationship between synonymous codon bias and codon-anticodon binding strength in human genes?
	Shi XF; Huang JF; Liang CR; Liu SQ; Xie J; Liu CQ*; xfshi@263.com
	2001
发表期刊	CHINESE SCIENCE BULLETIN
ISSN	1001-6538
卷号	46 期号:12 页码:1015-1019
合作性质	其它
摘要	Synonymous codon bias has been examined in 78 human genes (19967 codons) and measured by relative synonymous codon usage (RSCU). Relative frequencies of all kinds of dinucleotides in 2,3 or 3,4 codon positions have been calculated, and codon-anticodon binding strength has been estimated by the stacking energies of codon-anticodon bases in Watson-Crick pairs. The data show common features in synonymous codon bias for all codon families in human genes: all C-ending codons, which possess the strongest codon-anticodon binding energies, are the most favored codons in almost all codon families, and those codons with medium codon-anticodon binding energies are avoided. Data analysis suggests that besides isochore and genome signature, codon-anticodon binding strength may be closely related to synonymous codon choice in human genes. The join-effect of these factors on human genes results in the common features in codon bias.
关键词	Codon Bias Synonymous Codons Human Genes
资助者	This work was supported by the National Natural Science Foundation of China (Grant No. 39970412) and the sub-project of the “95” Key Project of the Chinese Academy of Sciences. ; This work was supported by the National Natural Science Foundation of China (Grant No. 39970412) and the sub-project of the “95” Key Project of the Chinese Academy of Sciences. ; This work was supported by the National Natural Science Foundation of China (Grant No. 39970412) and the sub-project of the “95” Key Project of the Chinese Academy of Sciences. ; This work was supported by the National Natural Science Foundation of China (Grant No. 39970412) and the sub-project of the “95” Key Project of the Chinese Academy of Sciences.
收录类别	SCI
语种	英语
资助者	This work was supported by the National Natural Science Foundation of China (Grant No. 39970412) and the sub-project of the “95” Key Project of the Chinese Academy of Sciences. ; This work was supported by the National Natural Science Foundation of China (Grant No. 39970412) and the sub-project of the “95” Key Project of the Chinese Academy of Sciences. ; This work was supported by the National Natural Science Foundation of China (Grant No. 39970412) and the sub-project of the “95” Key Project of the Chinese Academy of Sciences. ; This work was supported by the National Natural Science Foundation of China (Grant No. 39970412) and the sub-project of the “95” Key Project of the Chinese Academy of Sciences.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/4881
专题	结构生物信息学细胞与分子进化开放实验室
通讯作者	xfshi@263.com
作者单位	Cellular and Molecular Evolutionary Laboratory, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China
推荐引用方式 GB/T 7714	Shi XF,Huang JF,Liang CR,et al. Is there a close relationship between synonymous codon bias and codon-anticodon binding strength in human genes?[J]. CHINESE SCIENCE BULLETIN,2001,46(12):1015-1019.
APA	Shi XF.,Huang JF.,Liang CR.,Liu SQ.,Xie J.,...&xfshi@263.com.(2001).Is there a close relationship between synonymous codon bias and codon-anticodon binding strength in human genes?.CHINESE SCIENCE BULLETIN,46(12),1015-1019.
MLA	Shi XF,et al."Is there a close relationship between synonymous codon bias and codon-anticodon binding strength in human genes?".CHINESE SCIENCE BULLETIN 46.12(2001):1015-1019.

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