Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey

	Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey
	Wang JH 1,2,3; Zhang B 1,2,3; Meng ZQ 1,2,3; Sun NL 1,2,3; Ma MX 4; Zhang HX 1,2; Tang XD 5; Sanford LD 5; Wilson FAW 1,2; Hu XT1,2; Carlson S 6; Ma YY1,2; xthu@mail.kiz.ac.cn ; yuanma0716@vip.sina.com
	2007
发表期刊	DEVELOPMENTAL NEUROBIOLOGY
ISSN	1932-8451
卷号	67 期号:13 页码:1731-1741
摘要	Monkeys have strong abilities to remember the visual properties of potential food sources for survival in the nature. The present study demonstrated the first observations of rhesus monkeys learning to solve complex spatial mazes in which routes were guided by visual cues. Three monkeys were trained in a maze (6 m x 6 m) included of four different mazes. We recorded the cue and cup errors, latencies, and pathway for each trial. The data showed that monkeys learned the target place after three days in the first maze and spent a shorter time in learning the following mazes. The maze was an efficient method to measure the ability and proceeding of spatial memory in monkeys. Moreover, working memory can also be tested by using the maze. MK-801 at 0.02 mg/kg but not at 0.005 mg/kg impaired monkeys' retrieval of spatial memory after they learned all four mazes. The present maze may provide an efficient method to help bridging the gap in cognition between nonhuman primates and humans, and in particular to gain insight into human cognitive function and dysfunction.
关键词	Maze Mk-801 Rhesus Monkey Spatial Memory Working Memory
资助者	National Science Foundation of China; contract grant numbers: NSFC 30470553, 30530270. 973 Program; contract grant number: 2005CB522803. Chinese-Finnish International Collabora- tion Project-Neuro; contract grant number: 30621130076. National Key Technologies R&D Pro- gram. the Academy of Finland (National Cen- ter of Excellence Program) and research grant from the University of Helsinki. ; National Science Foundation of China; contract grant numbers: NSFC 30470553, 30530270. 973 Program; contract grant number: 2005CB522803. Chinese-Finnish International Collabora- tion Project-Neuro; contract grant number: 30621130076. National Key Technologies R&D Pro- gram. the Academy of Finland (National Cen- ter of Excellence Program) and research grant from the University of Helsinki. ; National Science Foundation of China; contract grant numbers: NSFC 30470553, 30530270. 973 Program; contract grant number: 2005CB522803. Chinese-Finnish International Collabora- tion Project-Neuro; contract grant number: 30621130076. National Key Technologies R&D Pro- gram. the Academy of Finland (National Cen- ter of Excellence Program) and research grant from the University of Helsinki. ; National Science Foundation of China; contract grant numbers: NSFC 30470553, 30530270. 973 Program; contract grant number: 2005CB522803. Chinese-Finnish International Collabora- tion Project-Neuro; contract grant number: 30621130076. National Key Technologies R&D Pro- gram. the Academy of Finland (National Cen- ter of Excellence Program) and research grant from the University of Helsinki.
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收录类别	SCI
语种	英语
资助者	National Science Foundation of China; contract grant numbers: NSFC 30470553, 30530270. 973 Program; contract grant number: 2005CB522803. Chinese-Finnish International Collabora- tion Project-Neuro; contract grant number: 30621130076. National Key Technologies R&D Pro- gram. the Academy of Finland (National Cen- ter of Excellence Program) and research grant from the University of Helsinki. ; National Science Foundation of China; contract grant numbers: NSFC 30470553, 30530270. 973 Program; contract grant number: 2005CB522803. Chinese-Finnish International Collabora- tion Project-Neuro; contract grant number: 30621130076. National Key Technologies R&D Pro- gram. the Academy of Finland (National Cen- ter of Excellence Program) and research grant from the University of Helsinki. ; National Science Foundation of China; contract grant numbers: NSFC 30470553, 30530270. 973 Program; contract grant number: 2005CB522803. Chinese-Finnish International Collabora- tion Project-Neuro; contract grant number: 30621130076. National Key Technologies R&D Pro- gram. the Academy of Finland (National Cen- ter of Excellence Program) and research grant from the University of Helsinki. ; National Science Foundation of China; contract grant numbers: NSFC 30470553, 30530270. 973 Program; contract grant number: 2005CB522803. Chinese-Finnish International Collabora- tion Project-Neuro; contract grant number: 30621130076. National Key Technologies R&D Pro- gram. the Academy of Finland (National Cen- ter of Excellence Program) and research grant from the University of Helsinki.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5515
专题	科研部门_神经系统编码（胡新天）科研部门_动物模型与人类重大疾病机理重点实验室认知障碍病理学中国科学院昆明灵长类研究中心
通讯作者	xthu@mail.kiz.ac.cn; yuanma0716@vip.sina.com
作者单位	1.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China 2.Kunming Primate Center, Chinese Academy of Sciences, Kunming, Yunnan, People’s Republic of China 3.Graduate School of Chinese Academy of Sciences, Beijing, People’s Republic of China 4.Department of Psychology, Jilin University, Chang Chun, People’s Republic of China 5.Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, Virginia, U.S.A 6.Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland and Medical School, University of Tampere, Tampere, Finland
推荐引用方式 GB/T 7714	Wang JH,Zhang B,Meng ZQ,et al. Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey[J]. DEVELOPMENTAL NEUROBIOLOGY,2007,67(13):1731-1741.
APA	Wang JH.,Zhang B.,Meng ZQ.,Sun NL.,Ma MX.,...&yuanma0716@vip.sina.com.(2007).Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey.DEVELOPMENTAL NEUROBIOLOGY,67(13),1731-1741.
MLA	Wang JH,et al."Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey".DEVELOPMENTAL NEUROBIOLOGY 67.13(2007):1731-1741.

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