Dissociated large-scale functional connectivity networks of the precuneus in medication-naive first-episode depression

	Dissociated large-scale functional connectivity networks of the precuneus in medication-naive first-episode depression
	Peng DH 1; Liddle EB 2,3; Iwabuchi SJ 2,3; Zhang C 1,5; Wu ZG 1; Liu J 4; Jiang KD 4; Xu L5 ; Liddle PF 2,3; Palaniyappan L2,3; Fang YR1; Lena.Palaniyappan@nottingham.ac.uk ; yirufang@gmail.com
	2015
发表期刊	PSYCHIATRY RESEARCH-NEUROIMAGING
卷号	232 期号:3 页码:250-256
合作性质	其它
摘要	An imbalance in neural activity within large-scale networks appears to be an important pathophysiological aspect of depression. Yet, there is little consensus regarding the abnormality within the default mode network (DMN) in major depressive disorder (MDD). In the present study, 16 first-episode, medication-naive patients with MDD and 16 matched healthy controls underwent functional magnetic resonance imaging (fMRI) at rest. With the precuneus (a central node of the DMN) as a seed region, functional connectivity (PC) was measured across the entire brain. The association between the PC of the precuneus and overall symptom severity was assessed using the Hamilton Depression Rating Scale. Patients with MDD exhibited a more negative relationship between the precuneus and the non-DMN regions, including the sensory processing regions (fusiform gyrus, postcentral gyrus) and the secondary motor cortex (supplementary motor area and precentral gyms). Moreover, greater severity of depression was associated with greater anti-correlation between the precuneus and the temporo-parietal junction as well as stronger positive connectivity between the precuneus and the dorsomedial prefrontal cortex. These results indicate that dissociated large-scale networks of the precuneus may contribute to the clinical expression of depression in MDD.
关键词	Depression Functional Connectivity Network Precuneus Functional Magnetic Resonance Imaging Resting State
资助者	This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study.
收录类别	SCI
语种	英语
资助者	This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study. ; This work was partly funded by grants from Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11), the Science and Technology Commission of Shang- hai Municipality (Grant nos. 114119a5500 and 134119a6200), the Shanghai Health Bureau (Grant no. GWHW201208), the Ministry of Science and Technology of China (grant no. 2012BAI01B04), and the National Natural Science Foundation of China (Grant no. 91232719). LP received support from the Wellcome Trust (Research Training Fellowship WT096002/z/11) during the course of this study.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/8346
专题	科研部门_学习记忆的分子神经机制（徐林）科研部门_动物模型与人类重大疾病机理重点实验室分子病理学
通讯作者	Lena.Palaniyappan@nottingham.ac.uk; yirufang@gmail.com
作者单位	1.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China 2.Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham NG7 2TU, UK 3.Center for Translational Neuroimaging, Institute of Mental Health, Nottinghamshire Healthcare NHS Trust, Nottingham NG7 2TU, UK 4.Huashan Hospital, Shanghai Medical College of Fudan University, Fudan University, Shanghai 200032, China 5.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China
推荐引用方式 GB/T 7714	Peng DH,Liddle EB,Iwabuchi SJ,et al. Dissociated large-scale functional connectivity networks of the precuneus in medication-naive first-episode depression[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,232(3):250-256.
APA	Peng DH.,Liddle EB.,Iwabuchi SJ.,Zhang C.,Wu ZG.,...&yirufang@gmail.com.(2015).Dissociated large-scale functional connectivity networks of the precuneus in medication-naive first-episode depression.PSYCHIATRY RESEARCH-NEUROIMAGING,232(3),250-256.
MLA	Peng DH,et al."Dissociated large-scale functional connectivity networks of the precuneus in medication-naive first-episode depression".PSYCHIATRY RESEARCH-NEUROIMAGING 232.3(2015):250-256.

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