Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin

	Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin
	Wei L 1; Dong L 2,3; Zhao TY 4; You DW 2; Liu R 1; Hu H 2; Yang HL 2; Lai R*1,2; rlai72@njau.edu.cn
	2011
发表期刊	BIOCHIMIE
卷号	93 期号:6 页码:995-1000
合作性质	其它
摘要	Anntoxin is the first gene-encoded neurotoxin identified from amphibians, which is a 60-residue neurotoxin peptide, acting as an inhibitor of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channel (VGSC). Sodium channels have been considered as therapeutic targets for pain. Several animal models of persistent inflammatory and neuropathic pain (tail-flick test, hot plate test, acetic acid-induced writhing test, formalin-induced paw licking, carrageenan-induced paw edema) were used to test analgesic functions of recombinant anntoxin (r-anntoxin). In all these animal models, r-anntoxin showed strong analgesic functions. R-anntoxin obviously inhibited secretions of both tumor necrosis factor alpha (TNF-alpha) and cyclooxygenase-2 (COX-2). Histopathological study indicated that r-anntoxin reduced the edematous epidermis induced by carrageenan. All these results indicate that r-anntoxin has strong analgesic and anti-inflammatory activities
关键词	Amphibian Skin Neurotoxin Analgesic Anti-inflammation
资助者	This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025) and the Ministry of Science and Technology (2010CB529800). ; This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025) and the Ministry of Science and Technology (2010CB529800). ; This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025) and the Ministry of Science and Technology (2010CB529800). ; This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025) and the Ministry of Science and Technology (2010CB529800).
收录类别	SCI
语种	英语
资助者	This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025) and the Ministry of Science and Technology (2010CB529800). ; This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025) and the Ministry of Science and Technology (2010CB529800). ; This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025) and the Ministry of Science and Technology (2010CB529800). ; This work was supported by Chinese National Natural Science Foundation (30830021, 30800185, 31025025) and the Ministry of Science and Technology (2010CB529800).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/353002/6627
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	rlai72@njau.edu.cn
作者单位	1.Key Laboratory of Microbiological Engineering of Agricultural Environment, Ministry of Agriculture, Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100009, China 4.Beijing Institute of Microbiology and Epidemiology, the Academy of Military Medical Sciences, Beijing, China
推荐引用方式 GB/T 7714	Wei L,Dong L,Zhao TY,et al. Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin[J]. BIOCHIMIE,2011,93(6):995-1000.
APA	Wei L.,Dong L.,Zhao TY.,You DW.,Liu R.,...&rlai72@njau.edu.cn.(2011).Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin.BIOCHIMIE,93(6),995-1000.
MLA	Wei L,et al."Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin".BIOCHIMIE 93.6(2011):995-1000.

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