| Characterization of the immune defense related tissues, cells, and genes in amphioxus | |
| Lin YS1; Chen DY1,2; Zhang W1; Cai ZP1; Chen ZK1; Zhang N1; Mao BY*3; Zhang HW*1; mao@mail.kiz.ac.cn; zhw@sdu.edu.cn | |
| 2011 | |
| 发表期刊 | SCIENCE CHINA-LIFE SCIENCES
 |
| 卷号 | 54期号:11页码:999-1004 |
| 合作性质 | 其它 |
| 摘要 | Amphioxus is an important animal model for phylogenetic analysis, including comparative immunology. Exploring the immune system in amphioxus contributes to our understanding of the origin and evolution of the vertebrate immune system. We investigated the amphioxus immune system using ultrastructural examination and in situ hybridization. The expression patterns of TLR1 (toll-like receptor 1), C1Q (complement component 1, q subcomponent), ECSIT (evolutionarily conserved signaling intermediate in Toll pathways), SoxC, DDAHa (Dimethylarginine dimethylaminohydrolase a), and NOS (nitric oxide synthase) show that these genes play key roles in amphioxus immunity. Our results suggest that the epidermis and alimentary canal epithelium may play important roles in immune defense, while macrophages located in the coelom and so-called lymph spaces may also be crucial immune cells |
| 关键词 | Amphioxus Epidermis Alimentary Canal Macrophages Immunity Evolution |
| 资助者 | This work was supported by the National Natural Science Foundation of China (Grant Nos. 30570967, 30671072 and 30700434), Natural Science Foundation of Shandong Province (Grant No. Y2007D20), and Ministry of Science and Technology of China (Grant Nos. 2007CB815800 and 2007CB947100). ; This work was supported by the National Natural Science Foundation of China (Grant Nos. 30570967, 30671072 and 30700434), Natural Science Foundation of Shandong Province (Grant No. Y2007D20), and Ministry of Science and Technology of China (Grant Nos. 2007CB815800 and 2007CB947100). ; This work was supported by the National Natural Science Foundation of China (Grant Nos. 30570967, 30671072 and 30700434), Natural Science Foundation of Shandong Province (Grant No. Y2007D20), and Ministry of Science and Technology of China (Grant Nos. 2007CB815800 and 2007CB947100). ; This work was supported by the National Natural Science Foundation of China (Grant Nos. 30570967, 30671072 and 30700434), Natural Science Foundation of Shandong Province (Grant No. Y2007D20), and Ministry of Science and Technology of China (Grant Nos. 2007CB815800 and 2007CB947100). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by the National Natural Science Foundation of China (Grant Nos. 30570967, 30671072 and 30700434), Natural Science Foundation of Shandong Province (Grant No. Y2007D20), and Ministry of Science and Technology of China (Grant Nos. 2007CB815800 and 2007CB947100). ; This work was supported by the National Natural Science Foundation of China (Grant Nos. 30570967, 30671072 and 30700434), Natural Science Foundation of Shandong Province (Grant No. Y2007D20), and Ministry of Science and Technology of China (Grant Nos. 2007CB815800 and 2007CB947100). ; This work was supported by the National Natural Science Foundation of China (Grant Nos. 30570967, 30671072 and 30700434), Natural Science Foundation of Shandong Province (Grant No. Y2007D20), and Ministry of Science and Technology of China (Grant Nos. 2007CB815800 and 2007CB947100). ; This work was supported by the National Natural Science Foundation of China (Grant Nos. 30570967, 30671072 and 30700434), Natural Science Foundation of Shandong Province (Grant No. Y2007D20), and Ministry of Science and Technology of China (Grant Nos. 2007CB815800 and 2007CB947100). |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/353002/6865 |
| 专题 | 科研部门_发育生物学（毛炳宇） |
| 通讯作者 | mao@mail.kiz.ac.cn; zhw@sdu.edu.cn |
| 作者单位 | 1.Life Science College, Shandong University, Key Laboratory of Experimental Teratology of Ministry of Education of China, Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Jinan 250100, China 2.Medical School, Nankai University, Tianjin 300071, China 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Lin YS,Chen DY,Zhang W,et al. Characterization of the immune defense related tissues, cells, and genes in amphioxus[J]. SCIENCE CHINA-LIFE SCIENCES,2011,54(11):999-1004. |
| APA | Lin YS.,Chen DY.,Zhang W.,Cai ZP.,Chen ZK.,...&zhw@sdu.edu.cn.(2011).Characterization of the immune defense related tissues, cells, and genes in amphioxus.SCIENCE CHINA-LIFE SCIENCES,54(11),999-1004. |
| MLA | Lin YS,et al."Characterization of the immune defense related tissues, cells, and genes in amphioxus".SCIENCE CHINA-LIFE SCIENCES 54.11(2011):999-1004. |
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