Modular architecture of metabolic brain network and its effects on the spread of perturbation impact
Zhang, TH; Huang, Q; Jiao, CX; Liu, H; Nie, BB; Liang, SX; Li, PL; Sun, X; Feng, T; Xu, L; Shan, BC
2019
Source PublicationNEUROIMAGE
ISSN1053-8119
Volume186Pages:146-154
AbstractMetabolic brain network, which is based on functional correlation patterns of F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) images, has been widely applied in both basic and clinical neuroscience. Exploring the properties of the metabolic brain network can provide valuable insight to the physiologic and pathologic processes of the brain. Based on the network theory, modular architecture has the ability to limit the spread of local perturbation impact and therefore modular networks are more robust against external damage. However, whether the metabolic brain network has modular architecture remains unknown. Methods: 77 rats performed F-18-FDG PET brain imaging. The metabolic brain network was then constructed by measuring interregional metabolic correlation in inter-subject manner. Afterwards, modular architecture of the network was detected by a greedy algorithm. Further, we perturbed the metabolic brain network by inducing focal photothrombotic ischemia in the bilateral motor cortex and then measured the glucose metabolic change of each brain region using FDG-PET. Results: A significant modular architecture was found in the metabolic brain network. The network could be divided into four modules which corresponding approximately to executive, learning/memory, visual/auditory and sensorimotor processing functional domains. After inducing the focal ischemia on the bilateral motor cortex, most of the significantly changed brain regions (13 of 17) belong to the sensorimotor module. Conclusion: Our results revealed an inherent modular architecture in the metabolic brain network and gave an experimental evidence that the modularity of the metabolism brain network could limit the spread of local perturbation impact.
Indexed BySCIE
Language英语
Document Type期刊论文
Identifierhttp://ir.kiz.ac.cn:8080/handle/152453/12553
Collection动物模型与人类重大疾病机理重点实验室_学习记忆的分子神经机制(徐林)
Recommended Citation
GB/T 7714
Zhang, TH,Huang, Q,Jiao, CX,et al. Modular architecture of metabolic brain network and its effects on the spread of perturbation impact[J]. NEUROIMAGE,2019,186:146-154.
APA Zhang, TH.,Huang, Q.,Jiao, CX.,Liu, H.,Nie, BB.,...&Shan, BC.(2019).Modular architecture of metabolic brain network and its effects on the spread of perturbation impact.NEUROIMAGE,186,146-154.
MLA Zhang, TH,et al."Modular architecture of metabolic brain network and its effects on the spread of perturbation impact".NEUROIMAGE 186(2019):146-154.
Files in This Item:
File Name/Size DocType Version Access License
2019070503.pdf(2318KB)期刊论文出版稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, TH]'s Articles
[Huang, Q]'s Articles
[Jiao, CX]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, TH]'s Articles
[Huang, Q]'s Articles
[Jiao, CX]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, TH]'s Articles
[Huang, Q]'s Articles
[Jiao, CX]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.