Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma
Yang, H; Mo, CZ; Xun, Y; Liu, LG; Li, WX; Guan, JY; Liu, J; Wu, JQ; Yang, AP; Zheng, SG; Liu, DH; Liu, F
2019
Source PublicationAMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
ISSN1943-8141
Volume11Issue:4Pages:2370-2381
AbstractObjective: To investigate the underlying molecular mechanisms contributing to oral squamous cell carcinoma (OSCC) cell resistance to the epidermal growth factor receptor (EGFR) inhibitor. Materials and methods: OSCC cell lines HSC-2 and HSC-3 were assessed in vitro for drug treatment, cell viability, and gene expression and the online gene expression in OSCC tissues was analyzed for association with OSCC prognosis. Results: HSC-2 and HSC-3 cells expressed high EGFR levels, but hepatocyte growth factor (HGF) treatment induced cetuximab resistance, whereas the Met inhibitor PHA-665752 as well as Met siRNA was able to restore OSCC cell sensitivity to cetuximab. HGF treatment induced tumor cells to express p-Akt and p-ERK1/2. In contrast, the activity of Akt and ERK1/2 was suppressed by treatment with PHA-665752, Met siRNA, or their combination. Furthermore, Met was highly expressed in OSCC tissues and associated with a poor patient survival, while Met/HGF-activated Akt also was associated with a poor patient survival. Conclusions: This study demonstrates that Met/HGF expression results in OSCC resistance to cetuximab and tumor recurrence after cetuximab therapy; thus, inhibition of Met/HGF activity could restore OSCC sensitivity to cetuximab.
Indexed BySCIE
Language英语
Document Type期刊论文
Identifierhttp://ir.kiz.ac.cn:8080/handle/152453/12555
Collection动物模型与人类重大疾病机理重点实验室_学习记忆的分子神经机制(徐林)
Recommended Citation
GB/T 7714
Yang, H,Mo, CZ,Xun, Y,et al. Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2019,11(4):2370-2381.
APA Yang, H.,Mo, CZ.,Xun, Y.,Liu, LG.,Li, WX.,...&Liu, F.(2019).Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,11(4),2370-2381.
MLA Yang, H,et al."Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 11.4(2019):2370-2381.
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