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	Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey
	Huang H1,2; Ya JR2,3; Tian CY5; Ren H3; Carlson S6; Yu HL1; Chen F*7; Wang JH*2; Wu Z2,3; Wen CM2,3; Zheng SY4; Fenger0802@163.com; wangjh@mail.kiz.ac.cn
	2016
发表期刊	MEDICAL SCIENCE MONITOR
卷号	22期号:X页码:1752-1760
摘要	Background: Sensory gating, often described as the ability to filter out irrelevant information that is repeated in close temporal proximity, is essential for the selection, processing, and storage of more salient information. This study aimed to test the effect of sensory gating under anesthesia in the prefrontal cortex (PFC) of monkeys following injection of bromocriptine, haloperidol, and phencyclidine (PCP).  Material/Methods: We used an auditory evoked potential that can be elicited by sound to examine sensory gating during treatment with haloperidol, bromocriptine, and PCP in the PFC in the cynomolgus monkey. Scalp electrodes were located in the bilateral PFC and bilateral temporal, bilateral parietal, and occipital lobes. Administration of bromocriptine (0.313 mg/kg, 0.625 mg/kg, and 1.25 mg/kg), haloperidol (0.001 mg/kg, 0.01 mg/kg, and 0.05 mg/kg), and the N-methyl-D-aspartic acid receptor antagonist PCP (0.3 mg/kg) influenced sensory gating.  Results: We demonstrated the following: (1) Administration of mid-dose bromocriptine disrupted sensory gating (N100) in the right temporal lobe, while neither low-dose nor high-dose bromocriptine impaired gating. (2) Low-dose haloperidol impaired gating in the right prefrontal cortex. Mid-dose haloperidol disrupted sensory gating in left occipital lobe. High-dose haloperidol had no obvious effect on sensory gating. (3) Gating was impaired by PCP in the left parietal lobe.  Conclusions: Our studies showed that information processing was regulated by the dopaminergic system, which might play an important role in the PFC. The dopaminergic system influenced sensory gating in a dose-and region-dependent pattern, which might modulate the different stages that receive further processing due to novel information.
关键词	Bromocriptine Dopamine Haloperidol Prefrontal Cortex Sensory Gating
资助者	This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01)
收录类别	SCI
语种	英语
资助者	This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01) ; This study was supported by National Science Foundation of China (NSFC 31271168, 31571109, 81260218, 81460261, Chinese- Finnish Joint Project 813111172), Yunnan Key Program of Science and Technology (2014FC005), and Kunming Medical University Doctoral Funds for Creative Study (2015D01)
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/10300
专题	科研部门_神经系统编码（胡新天） 科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	Fenger0802@163.com; wangjh@mail.kiz.ac.cn
作者单位	1.Second Department of Neurosurgery, First Affiliation Hospital of Kunming Medical University, Kunming, Yunnan, P.R. China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, P.R. China 3.Department of Neurology, First Affiliation Hospital of Kunming Medical University, Kunming, Yunnan, P.R. China 4.Department of Neurosurgery, First Affiliation Hospital of Nanchang University, Nanchang, Jiangxi, P.R. China 5.Hainan Jingang Biological Technology Co., Ltd., Haikou, Hainan, P.R. China 6.Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland 7.Department of Radiology, People’s Hospital of Hainan, Haikou, Hainan, P.R. China
推荐引用方式 GB/T 7714	Huang H,Ya JR,Tian CY,et al. Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey[J]. MEDICAL SCIENCE MONITOR,2016,22(X):1752-1760.
APA	Huang H.,Ya JR.,Tian CY.,Ren H.,Carlson S.,...&wangjh@mail.kiz.ac.cn.(2016).Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey.MEDICAL SCIENCE MONITOR,22(X),1752-1760.
MLA	Huang H,et al."Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey".MEDICAL SCIENCE MONITOR 22.X(2016):1752-1760.

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