| Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging | |
Tang X1; Wu D1; Wang YJ1; Wu FF1; Li XL1; Bai F1; Chen XC3; Xu L4,5 ; Gu LH1; Ren QG*1; Zhang ZJ*1; Nie BB2; Qi XY1; janemengzhang@vip.163.com; renqingguo1976@163.com
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| 2016 | |
| 发表期刊 | ONCOTARGET
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| 卷号 | 7期号:36页码:57556-57570 |
| 合作性质 | 其它 |
| 摘要 | Dysfunction of neuronal activity is a major and early contributor to cognitive impairment in Alzheimer's disease (AD). To investigate neuronal activity alterations at early stage of AD, we encompassed behavioral testing and in vivo manganese-enhanced magnetic resonance imaging (MEMRI) in 5XFAD mice at early ages (1-, 2-, 3- and 5-month). The 5XFAD model over-express human amyloid precursor protein (APP) and presenilin 1 (PS1) harboring five familial AD mutations, which have a high APP expression correlating with a high burden and an accelerated accumulation of the 42 amino acid species of amyloid-β. In the Morris water maze, 5XFAD mice showed longer escape latency and poorer memory retention. In the MEMRI, 5XFAD mice showed increased signal intensity in the brain regions involved in spatial cognition, including the entorhinal cortex, the hippocampus, the retrosplenial cortex and the caudate putamen. Of note, the observed alterations in spatial cognition were associated with increased MEMRI signal intensity. These findings indicate that aberrant increased basal neuronal activity may contribute to the spatial cognitive function impairment at early stage of AD, and may further suggest the potential use of MEMRI to predict cognitive impairments. Early intervention that targets aberrant neuronal activity may be crucial to prevent cognitive impairment. |
| 关键词 | Alzheimer’s Disease 5xfad Mice Cognition Neuroimaging Manganese Enhanced Mri Pathology Section |
| 资助者 | This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707 Qing-guo Ren, 81420108012 Zhi-jun Zhang), the National Major Science and Technology Program of China (No. 2012ZX09506-001-009 Zhi-Jun Zhang), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Provincial Clinical Medical Research Center (BL2013025), National High-tech R.D Program (863 Program) (No.2015AA020508), National Basic Research Program of China (2013CB835103) and Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/10388 |
| 专题 | 科研部门_学习记忆的分子神经机制（徐林） 科研部门_动物模型与人类重大疾病机理重点实验室 |
| 通讯作者 | janemengzhang@vip.163.com; renqingguo1976@163.com |
| 作者单位 | 1.Department of Neurology, Affiliated ZhongDa Hospital, Neuropsychiatric Institute, School of Medicine, Southeast University, Nanjing, Jiangsu, China 2.Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China 3.Department of Neurology and Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian, China 4.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 5.Graduate School of Chinese Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Tang X,Wu D,Wang YJ,et al. Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging[J]. ONCOTARGET,2016,7(36):57556-57570. |
| APA | Tang X.,Wu D.,Wang YJ.,Wu FF.,Li XL.,...&renqingguo1976@163.com.(2016).Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging.ONCOTARGET,7(36),57556-57570. |
| MLA | Tang X,et al."Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging".ONCOTARGET 7.36(2016):57556-57570. |
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