| Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer | |
| Li YR1; Xu X1; Tsang S10; Wang W2; Lu ZH5,6; Zhang XQ1; Bolund L1,15; Kristiansen K1,16; Song LT1,2,3,4; Wang J1; Yang HM*1; Dean M*11; Wang J*1,16,17; Hou Y1,5,6; Li ZS7,8,9; yanghm@genomics.cn; deanm@mail.nih.gov; wangj@genomics.cn | |
| 2012 | |
| 发表期刊 | GIGASCIENCE
 |
| 卷号 | 1期号:X页码:e12 |
| 合作性质 | 其它 |
| 摘要 | Background: Cancers arise through an evolutionary process in which cell populations are subjected to selection; however, to date, the process of bladder cancer, which is one of the most common cancers in the world, remains unknown at a single-cell level. Results: We carried out single-cell exome sequencing of 66 individual tumor cells from a muscle-invasive bladder transitional cell carcinoma (TCC). Analyses of the somatic mutant allele frequency spectrum and clonal structure revealed that the tumor cells were derived from a single ancestral cell, but that subsequent evolution occurred, leading to two distinct tumor cell subpopulations. By analyzing recurrently mutant genes in an additional cohort of 99 TCC tumors, we identified genes that might play roles in the maintenance of the ancestral clone and in the muscle-invasive capability of subclones of this bladder cancer, respectively. Conclusions: This work provides a new approach of investigating the genetic details of bladder tumoral changes at the single-cell level and a new method for assessing bladder cancer evolution at a cell-population level. |
| 关键词 | Single-cell Exome Sequencing Bladder Cancer Tumor Evolution Population Genetics |
| 资助者 | This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. ; This work was supported by a National Basic Research Program of China (973 program no.2011CB809202;2011CB809203), the Chinese 863 program (no.2009AA022707), the Shenzhen Municipal Government of China (grants ZYC201005250020A ), the Key Laboratory Project Supported by Shenzhen City (grants CX B200903 110066A; CXB201108250096A), and Shenzhen Key Laboratory of Gene Bank for National Life Science. This project was also supported by a grant from the Innovative Research Team Project of GuangDong and the Guangdong Enterprise Key Laboratory of Human Disease Genomics, and in part by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. We also thank the Danish Natural Science Research Council for the Ole Rømer grant and the Shenzhen Municipal Government and the Local Government of Yantian District of Shenzhen for providing funding and an in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, USA. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/10400 |
| 专题 | 基因起源组 遗传资源与进化国家重点实验室 |
| 通讯作者 | yanghm@genomics.cn; deanm@mail.nih.gov; wangj@genomics.cn |
| 作者单位 | 1.BGI-Shenzhen, Beishan Industrial Zone, Beishan Road, Yantian, Shenzhen 518083, People’s Republic of Chin 2.CAS-Max Planck Junior Research Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), 32# Jiao-chang Road, Kunming, Yunnan 650223, People’s Republic of China 3.Graduate University of the Chinese Academy of Sciences, 19A Yuquanlu, Beijing 100049, People’s Republic of China 4.College of Life Sciences, Wuhan University, Luojia Hill, Wuhan 430072, People’s Republic of China 5.School of Biological Science and Medical Engineering, Southeast University, Sipailou 2#, Nanjing 210096, People’s Republic of China. 6.State Key Laboratory of Bioelectronics, Southeast University, Sipailou 2#, Nanjing 210096, People’s Republic of China. 7.Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, People’s Republic of China. 8.Department of Urology, Shenzhen Second People’s Hospital, Shenzhen 518035, People’s Republic of China. 9.The Institute of Urogenital Diseases, Shenzhen University, Shenzhen 518060, People’s Republic of China. 10.BioMatrix, LLC, 3029 Windy Knoll Court, Rockville, MD 20850, USA 11.Cancer and Inflammation Program, National Cancer Institute at Frederick, Building 560, Frederick, MD 21702, USA 12.School of Bioscience and Biotechnology, Guangzhou Higher Education Mega Centre, South China University of Technology, Panyu District, Guangzhou 510006, People’s Republic of China 13.Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Shenzhen PKU-HKUST Medical Center, Peking University Shenzhen Hospital, 1120 Lian Hua Road, Futian District, Shenzhen 518036, People’s Republic of China. 14.Department of Urology, Longgang Central Hospital, Shenhui Road, Longgang Town, Shenzhen 518116, People’s Republic of China. 15.Institute of Human Genetics, University of Aarhus, Aarhus 8100, Denmark. 16.The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, DK 2200, Denmark 17.Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, DK 2200, Denmark. |
| 推荐引用方式 GB/T 7714 | Li YR,Xu X,Tsang S,et al. Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer[J]. GIGASCIENCE,2012,1(X):e12. |
| APA | Li YR.,Xu X.,Tsang S.,Wang W.,Lu ZH.,...&wangj@genomics.cn.(2012).Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer.GIGASCIENCE,1(X),e12. |
| MLA | Li YR,et al."Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer".GIGASCIENCE 1.X(2012):e12. |
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