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KIZ OpenIR  > 科研部门  > 学习记忆的分子神经机制（徐林）
A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol
Zhang XB1; Jiang P1; Xiong ZQ1; Xu L2; Xu TL*1; Gong N1; Hu XL1; Fei D1; tlxu@ion.ac.cn
2008
发表期刊PLOS ONE
卷号3期号:10页码:e3386
合作性质其它
摘要Menthol is a widely-used cooling and flavoring agent derived from mint leaves. In the peripheral nervous system, menthol regulates sensory transduction by activating TRPM8 channels residing specifically in primary sensory neurons. Although behavioral studies have implicated menthol actions in the brain, no direct central target of menthol has been identified. Here we show that menthol reduces the excitation of rat hippocampal neurons in culture and suppresses the epileptic activity induced by pentylenetetrazole injection and electrical kindling in vivo. We found menthol not only enhanced the currents induced by low concentrations of GABA but also directly activated GABA(A) receptor (GABA(A)R) in hippocampal neurons in culture. Furthermore, in the CA1 region of rat hippocampal slices, menthol enhanced tonic GABAergic inhibition although phasic GABAergic inhibition was unaffected. Finally, the structure-effect relationship of menthol indicated that hydroxyl plays a critical role in menthol enhancement of tonic GABA(A)R. Our results thus reveal a novel cellular mechanism that may underlie the ambivalent perception and psychophysical effects of menthol and underscore the importance of tonic inhibition by GABA(A)Rs in regulating neuronal activity.
资助者This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35).
收录类别SCI
语种英语
资助者This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35).
文献类型期刊论文
条目标识符http://ir.kiz.ac.cn/handle/152453/10494
专题科研部门_学习记忆的分子神经机制（徐林）
通讯作者tlxu@ion.ac.cn
作者单位1.Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
2.Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
推荐引用方式
GB/T 7714		 Zhang XB,Jiang P,Xiong ZQ,et al. A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol[J]. PLOS ONE,2008,3(10):e3386.
APA Zhang XB.,Jiang P.,Xiong ZQ.,Xu L.,Xu TL*.,...&tlxu@ion.ac.cn.(2008).A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol.PLOS ONE,3(10),e3386.
MLA Zhang XB,et al."A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol".PLOS ONE 3.10(2008):e3386.
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