| Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice | |
| van den Buuse M*1,2,4; Morris M2; Chavez C1; Martin S1; Wang JH1,3; mvandenbuuse@mhri.edu.au | |
| 2004 | |
| 发表期刊 | BRITISH JOURNAL OF PHARMACOLOGY
 |
| 卷号 | 142期号:3页码:543-550 |
| 合作性质 | 其它 |
| 摘要 | 1 Stress is a risk factor in psychiatric illnesses such as schizophrenia. The aim of the present study was to investigate the effect of different circulating levels of the adrenal steroid corticosterone (CORT) on locomotor hyperactivity and prepulse inhibition of acoustic startle, two behavioural animal models of aspects of schizophrenia. 2 Male C57BL/6J mice (n = 10 per group) were anaesthetised with isoflurane and sham-operated or adrenalectomised (ADX). ADX mice were implanted with 50 mg pellets consisting of 100% cholesterol, or 2, 10 or 50 mg of CORT mixed with cholesterol. CORT pellet implantation dose dependently increased plasma CORT levels 3 weeks after surgery. Starting 1 week after surgery, mice were tested for prepulse inhibition after injection of saline or 5 mg kg(-1) of haloperidol. 3 In intact mice and in mice implanted with 10 mg of CORT, haloperidol treatment significantly increased prepulse inhibition (average values from 38 - 42 to 52%). Similar results were observed when testing the mice for amphetamine-induced locomotor hyperactivity (5 mg kg(-1)). In contrast, there was no significant effect of haloperidol in mice implanted either with cholesterol or 2 or 50 mg of CORT. 4 These results in behavioural animal models of schizophrenia suggest an important role of the stress hormone CORT in modulating dopaminergic activity in this illness. |
| 关键词 | Corticosterone Dopamine Prepulse Inhibition Locoinotor Hyperactivity Mice |
| 收录类别 | SCI |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/10614 |
| 专题 | 科研部门_神经系统编码（胡新天） |
| 通讯作者 | mvandenbuuse@mhri.edu.au |
| 作者单位 | 1.Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia 2.Department of Pharmacology, University of Melbourne, Melbourne, Australia 3.Section of Cognitive Brain Research, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650233, People’s Republic of China 4.Current address: Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia |
| 推荐引用方式 GB/T 7714 | van den Buuse M*,Morris M,Chavez C,et al. Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice[J]. BRITISH JOURNAL OF PHARMACOLOGY,2004,142(3):543-550. |
| APA | van den Buuse M*,Morris M,Chavez C,Martin S,Wang JH,&mvandenbuuse@mhri.edu.au.(2004).Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice.BRITISH JOURNAL OF PHARMACOLOGY,142(3),543-550. |
| MLA | van den Buuse M*,et al."Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice".BRITISH JOURNAL OF PHARMACOLOGY 142.3(2004):543-550. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2004142543.pdf（172KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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