Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction

	Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction
	Zhang FH 1; Debnath B 2; Zheng YT 3; Neamati N2; Long YQ1; Xu ZL 1; Yang LM 3; Song LR 1; neamati@umich.edu
	2017
发表期刊	European Journal of Medicinal Chemistry
卷号	125 期号:X 页码:1051-1063
合作性质	其它
摘要	Currently, three HIV-1 integrase (IN) active site-directed inhibitors are in clinical use for the treatment of HIV infection. However, emergence of drug resistance mutations have limited the promise of a long-term cure. As an alternative, allosteric inhibition of IN activity has drawn great attention and several of such inhibitors are under early stage clinical development. Specifically, inhibitors of IN and the cellular cofactor LEDGF/p75 remarkably diminish proviral integration in cells and deliver a potent reduction in viral replicative capacity. Distinct from the extensively studied 2-(quinolin-3-yl) acetic acid or 1H-indol-3-yl-2-hydroxy-4-oxobut-2-enoic acid chemotypes, this study discloses a new class of selective IN-LEDGF/p75 inhibitors without the carboxylic acid functionality. More significantly, 3-hydroxypicolinamides also show low micromolar inhibition against IN dimerization, providing novel dual IN inhibitors with in vitro therapeutically selective antiviral effect for further development. Finally, our shape-based ROCS pharmacophore model of the 3-hydroxypicolinamide class of compounds provides a new insight into the binding mode of these novel IN-LEDGF/p75 inhibitors.
关键词	3-hydroxypicolinamide Allosteric Inhibitor Dimerization Hiv-1 Integrase Ledgf/p75
资助者	The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610).
收录类别	SCI
语种	英语
资助者	The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610). ; The work in Long Laboratory was supported by the National Natural Science Foundation of China (81325020, 81361120410, 81321092 and 81123004) and the work in Neamati Laboratory was supported by the National Institutes of Health (NIH/NIAID grant R21 AI081610).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/10627
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	neamati@umich.edu
作者单位	1.CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China 2.Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-2800, USA 3.Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Zhang FH,Debnath B,Zheng YT,et al. Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction[J]. European Journal of Medicinal Chemistry,2017,125(X):1051-1063.
APA	Zhang FH.,Debnath B.,Zheng YT.,Neamati N.,Long YQ.,...&neamati@umich.edu.(2017).Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction.European Journal of Medicinal Chemistry,125(X),1051-1063.
MLA	Zhang FH,et al."Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction".European Journal of Medicinal Chemistry 125.X(2017):1051-1063.

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