| Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5. | |
| Xu XQ*1,2; Zhang B1; Andersen JF*2; Yang SL3; An S3; Ribeiro JM2; xu2003@smu.edu.cn; jandersen@niaid.nih.gov | |
| 2016 | |
| 发表期刊 | SCIENTIFIC REPORTS
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| 卷号 | 6期号:X页码:e36574 |
| 合作性质 | 其它 |
| 摘要 | Naturally occurring toxins have been invaluable tools for the study of structural and functional relationships of voltage-gated sodium channels (VGSC). Few studies have been made of potential channel-modulating substances from blood-feeding arthropods. He we describe the characterization FS50, a salivary protein from the flea, Xenopsylla cheopis, that exhibits an inhibitory activity against the NaV1.5 channel with an IC50 of 1.58 μM. The pore-blocking mechanism of this toxin is evident from the kinetics of activation and inactivation suggesting that FS50 does not interfere with the voltage sensor of NaV1.5. FS50 exhibits high specificity for NaV1.5, since 10 μM FS50 had no discernable effect on voltage-gated Na+, K+ and Ca2+ channels in rat dorsal root ganglia or VGSC forms individually expressed in HEK 293T cells. Furthermore, intravenous injection of FS50 into rats and monkeys elicited recovery from arrhythmia induced by BaCl2, as would be expected from a blockade of NaV1.5. The crystal structure of FS50 revealed a βαββ domain similar to that of scorpion β toxin and a small N-terminal βαβ domain. Site-directed mutagenesis experiments have implicated a basic surface including the side chains of Arg 6, His 11 and Lys 32 as potentially important in the FS50 NaV1.5 interaction. |
| 资助者 | This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. ; This work was supported in part by the Chinese National Natural Science Foundation (3137078), the Chinese Ministry of Science and Technology (2010CB529800) and the National Institutes of Health intramural research program of NIAID. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/10631 |
| 专题 | 科研部门_天然药物功能蛋白质学科组（赖仞） 科研部门_动物模型与人类重大疾病机理重点实验室 |
| 通讯作者 | xu2003@smu.edu.cn; jandersen@niaid.nih.gov |
| 作者单位 | 1.Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, Guangdong, China 2.The Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852 USA 3.The Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Xu XQ*,Zhang B,Andersen JF*,et al. Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5.[J]. SCIENTIFIC REPORTS,2016,6(X):e36574. |
| APA | Xu XQ*.,Zhang B.,Andersen JF*.,Yang SL.,An S.,...&jandersen@niaid.nih.gov.(2016).Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5..SCIENTIFIC REPORTS,6(X),e36574. |
| MLA | Xu XQ*,et al."Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5.".SCIENTIFIC REPORTS 6.X(2016):e36574. |
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| 2016110904.pdf（1346KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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