中国科学院昆明动物研究所机构知识库

QQ客服 官方微博 反馈留言

	Integrative transcriptomic analysis of NAFLD animal model reveals dysregulated genes and pathways in metabolism
	Yang WH1; He Y1; Wang J3; Liang J1; Dong Y1; Wang Q1; Hou ZL*1; Yang L*2; Liu SJ1; Gan L1; Zhang ZG1; hzl579@163.com; 13908864176@163.com
	2016
发表期刊	GENE
卷号	595期号:1页码:99-108
合作性质	其它
摘要	Dysregulation of metabolism in hepatocytes leads to hepatic diseases such as hepatitis and non-alcoholic fatty liver disease (NAFLD). NAFLD represents a spectrum of liver diseases ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). NASH is likely to progress to cirrhosis, liver failure and hepatocellular carcinoma, which lead to poor long-term prognosis. However, the exact mechanism of development of NAFLD is not well elucidated. In order to better understand the pathogenesis of NAFLD, we have performed an integrative analysis to livers from NAFLD rat models in a global view of the transcriptome. By systemic and integrative analyses, we have found that transport, angiogenesis and cell adhesion were upregulated in response to high fat diet feeding, which may cause a large amount of free fatty acid transport, hepatic fibrosis and hepatocytes injury. GO tree analysis has shown that angiogenesis was upregulated. GO term in response to high fat diet which may cause fibrosis. The pathway interaction network has indicated that upregulated "valine, leucine, and isoleucine metabolism" may decrease the serum concentration of branched-chain amino acid (BCAA). The enhanced degradation of BCAA in NAFLD animal models may lead to inhibition of the regeneration of hepatocytes, reducing the production of albumin, attenuating the inhibition of liver cancer and decreasing immunity. Overall, high fat diet upregulated a variety of metabolism which have converged at TCA cycle. High fatty has pushed the hepatic mitochondria to a "busy state". Comprehensively, genes participated in dysregulated biological process and metabolisms may be served as indicators for evaluation of NAFLD progression and therapeutic targets.
关键词	Non-alcoholic Fatty Liver Disease Animal Model Rna Sequencing Bioinformatic Analysis Metabolism
资助者	This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008).
收录类别	SCI
语种	英语
资助者	This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008). ; This work is supported by grants from National Natural Science Foundation of China (81460436) and grants from the “Special and JointProgram”ofYunnanProvinceScienceandTechnologyDepartment and Kunming Medical University (2015FA008).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/10754
专题	其他
通讯作者	hzl579@163.com; 13908864176@163.com
作者单位	1.Department of Geriatrics, Yan'an Affiliated Hospital of Kunming Medical University, Kunming 650051, Yunnan, People's Republic of China 2.Department of Central Laboratory, Yan'an Affiliated Hospital of Kunming Medical University, Kunming 650051, Yunnan, People's Republic of China 3.Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, People's Republic of China
推荐引用方式 GB/T 7714	Yang WH,He Y,Wang J,et al. Integrative transcriptomic analysis of NAFLD animal model reveals dysregulated genes and pathways in metabolism[J]. GENE,2016,595(1):99-108.
APA	Yang WH.,He Y.,Wang J.,Liang J.,Dong Y.,...&13908864176@163.com.(2016).Integrative transcriptomic analysis of NAFLD animal model reveals dysregulated genes and pathways in metabolism.GENE,595(1),99-108.
MLA	Yang WH,et al."Integrative transcriptomic analysis of NAFLD animal model reveals dysregulated genes and pathways in metabolism".GENE 595.1(2016):99-108.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2016122813.pdf（2165KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文

个性服务

推荐该条目

保存到收藏夹

查看访问统计

导出为Endnote文件

谷歌学术

谷歌学术中相似的文章

[Yang WH]的文章

[He Y]的文章

[Wang J]的文章

百度学术

百度学术中相似的文章

[Yang WH]的文章

[He Y]的文章

[Wang J]的文章

必应学术

必应学术中相似的文章

[Yang WH]的文章

[He Y]的文章

[Wang J]的文章

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。