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	Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions
	Ye LJ1,2,4; Bian H3; Ma YY*2; Chen F*5; Fan YD1; Wang ZB2; Yu HL*4; fenger0802@163.com, yuanma0716@sina.com,yhl308@126.net.
	2016
发表期刊	NEURAL REGENERATION RESEARCH
卷号	11期号:9页码:1464-1470
摘要	Rhesus monkey neural stem cells are capable of differentiating into neurons and glial cells. Therefore, neural stem cell transplantation can be used to promote functional recovery of the nervous system. Rhesus monkey neural stem cells (1 x 10(5) cells/mu L) were injected into bilateral hippocampi of rats with hippocampal lesions. Confocal laser scanning microscopy demonstrated that green fluorescent protein-labeled transplanted cells survived and grew well. Transplanted cells were detected at the lesion site, but also in the nerve fiber-rich region of the cerebral cortex and corpus callosum. Some transplanted cells differentiated into neurons and glial cells clustering along the ventricular wall, and integrated into the recipient brain. Behavioral tests revealed that spatial learning and memory ability improved, indicating that rhesus monkey neural stem cells noticeably improve spatial learning and memory abilities in rats with hippocampal lesions.
关键词	Nerve Regeneration Rhesus Monkey Neural Stem Cells Hippocampal Lesion Cell Transplantation Spatial Learning And Memory Abilities Neural Regeneration
资助者	This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China.
收录类别	SCI
语种	英语
资助者	This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China. ; This work was supported by the National Natural Science Foundation of China, No. 31571109, 81460261; the Chinese-Finnish Joint Project Fund, No. 813111172; a grant from the Yunnan Key Program of Science and Technology of China, No. 2014FC005; the Key Science and Technology Research Project Fund of Hainan Province of China, No. ZDYF2016156; the National Clinical Key Subject Construction Project Fund of China.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/10760
专题	认知障碍病理学 科研部门_神经系统编码（胡新天）
通讯作者	fenger0802@163.com, yuanma0716@sina.com,yhl308@126.net.
作者单位	1.Department of Pathology, Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan Province, China 3.Department of Physiology, Kunming Medical University, Kunming, Yunnan Province, China 4.Second Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China 5.Department of Radiology, Hainan General Hospital, Haikou, Hainan Province, China
推荐引用方式 GB/T 7714	Ye LJ,Bian H,Ma YY*,et al. Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions[J]. NEURAL REGENERATION RESEARCH,2016,11(9):1464-1470.
APA	Ye LJ.,Bian H.,Ma YY*.,Chen F*.,Fan YD.,...&fenger0802@163.com, yuanma0716@sina.com,yhl308@126.net..(2016).Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions.NEURAL REGENERATION RESEARCH,11(9),1464-1470.
MLA	Ye LJ,et al."Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions".NEURAL REGENERATION RESEARCH 11.9(2016):1464-1470.

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