The geographical distribution of grey wolves (Canis lupus) in China: a systematic review
Wang L1; Ma YP1,2; Wang GD*2; Zhou QJ2; Zhang YP1,2; Savolainen P3
2016
发表期刊Zoological Research
卷号37期号:6页码:315-326
摘要

The grey wolf (Canis lupus) is one of the most widely distributed terrestrial mammals, and its distribution and ecology in Europe and North America are largely well described. However, the distribution of grey wolves in southern China is still highly controversial. Several well-known western literatures stated that there were no grey wolves in southern China, while the presence of grey wolvesacross China has been indicated in A Guide to the Mammals of China, published by Princeton University Press. It is essential to solve this discrepancy since dogs may have originated from grey wolves in southern China. Therefore, we systematically investigated Chinese literatures about wild animal surveys and identified more than 100 articles and books that included information of the distribution of grey wolves in China. We also surveyed the collections of three Chinese natural museums and found 26 grey wolf skins specimens collected across China. Moreover, we investigated the fossil records in China and identified 25 archaeological sites with wolf remains including south China. In conclusion, with the comprehensive summary of Chinese literatures, museum specimens and fossil records, we demonstrate that grey wolves do distribute across all parts of the Chinese mainland, including the most southern parts.

关键词China Grey Wolf Distribution Conservation
资助者This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences
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语种英语
资助者This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences ; This study was supported by grants from the National Natural Science Foundation of China (91531303), the 973 program (2013CB835200 and 2013CB835202), the Breakthrough Project of Strategic Priority Program of the Chinese Academy of Sciences (XDB13000000), and grants from the Carl Trygger Foundation and the Agria and Swedish Kennel Club research foundation. GD Wang is supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences
文献类型期刊论文
条目标识符http://ir.kiz.ac.cn/handle/152453/10820
专题科研部门_分子进化与基因组多样性(张亚平)
遗传资源与进化国家重点实验室
作者单位1.State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan, Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province, Yunnan University, Kunming 650091, China
2.State Key Laboratory of Genetic Resources and Evolution, Yunnan Key Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
3.Science for Life Laboratory, Department of Gene Technology, KTH-Royal Institute of Technology, Solna 17165, Sweden
推荐引用方式
GB/T 7714
Wang L,Ma YP,Wang GD*,et al. The geographical distribution of grey wolves (Canis lupus) in China: a systematic review[J]. Zoological Research,2016,37(6):315-326.
APA Wang L,Ma YP,Wang GD*,Zhou QJ,Zhang YP,&Savolainen P.(2016).The geographical distribution of grey wolves (Canis lupus) in China: a systematic review.Zoological Research,37(6),315-326.
MLA Wang L,et al."The geographical distribution of grey wolves (Canis lupus) in China: a systematic review".Zoological Research 37.6(2016):315-326.
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