Lipidome determinants of maximal lifespan in mammals | |
Bozek K*1,2,13; Khrameeva EE3,4; Lewin GR6; Azpurua J8; Gorbunova V8; Liu Z11; Shi P11; Willmitzer L12; Reznick J5; Giavalisco P*12; Khaitovich P*1,2,3; Omerbašić D6; Bennett NC7 | |
2017 | |
发表期刊 | SCIENTIFIC REPORTS |
卷号 | 7期号:X页码:e5 |
摘要 | Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species' longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammal |
收录类别 | SCI |
语种 | 英语 |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kiz.ac.cn/handle/152453/10833 |
专题 | 遗传资源与进化国家重点实验室_进化与功能基因组学(施鹏) 遗传资源与进化国家重点实验室 |
作者单位 | 1.CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, 320 Yue Yang Road, Shanghai, 200031, China 2.Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103, Leipzig, Germany 3.Skoltech Center for Computational and Systems Biology, Skolkovo Institute for Science and Technology, Novaya st. 100, Skolkovo, 143025, Russia 4.Institute for Information Transmission Problems, Russian Academy of Sciences, Bolshoy Karetny per. 19/1, Moscow, 127051, Russia 5.Max-Delbrück Center for Molecular Medicine, Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa, South Africa 6.Max-Delbrück Center for Molecular Medicine, Robert-Rössle-Str. 10, 13092, Berlin, Germany 7.Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa, South Africa 8.University of Rochester, 434 Hutchison Hall, Rochester, NY, 14627-0211, USA 9.SILABE, Primatology Center, University Louis Pasteur, Strasbourg, 4 Rue Blaise Pascal, 67070, France 10.MR 7179/CNRS-MNHN, 1 avenue du Petit Chateu, 91800, Brunoy, France 11.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Dong Lu, Kunming, Yunnan, 650223, China 12.Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, 14476, Potsdam, Germany 13.Present address: Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa, 904-0495, Japan |
推荐引用方式 GB/T 7714 | Bozek K*,Khrameeva EE,Lewin GR,et al. Lipidome determinants of maximal lifespan in mammals[J]. SCIENTIFIC REPORTS,2017,7(X):e5. |
APA | Bozek K*.,Khrameeva EE.,Lewin GR.,Azpurua J.,Gorbunova V.,...&Bennett NC.(2017).Lipidome determinants of maximal lifespan in mammals.SCIENTIFIC REPORTS,7(X),e5. |
MLA | Bozek K*,et al."Lipidome determinants of maximal lifespan in mammals".SCIENTIFIC REPORTS 7.X(2017):e5. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
2017020809.pdf(3000KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论