NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo

	NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo
	Wang MN 1,2; Yang Y 1,2; Dong ZF 1,2; Cao J1,2; Xu L1,2,3; juncao@vip.163.com ; lxu@vip.163.com
	2006
发表期刊	NEUROREPORT
卷号	17 期号:12 页码:1343-1346
摘要	Behavioral stress facilitates long-term depression but impairs long-term potentiation in the hippocampus. Recent evidence in vitro demonstrates that the NIR2B-containing N-methyl-D-aspartate subtype glutamate receptor antagonist Ro25-6981 prevents the behavioral stress-facilitated hippocampal long-term depression. It is, however, unknown whether Ro25-6981 influences hippocampal long-term depression and long-term potentiation induction in vivo under stressful condition. Here, we found that infusion of Ro25-6981 (2.3 mu g in 6 mu l, intracerebroventricular for 10min) 30 min before low-frequency stimulation prevented the facilitation of hippocampal long-term depression by acute stress in anesthetized adult rats. Moreover, infusion of Ro25-6981 30min before high-frequency stimulation reversed stress-impaired hippocampal long-term potentiation. These results suggest that the NR2B-containing N-methyl-D-aspartate subtype glutamate receptors are crucial for the effects of behavioral stress on hippocampal long-term depression and long-term potentiation in vivo.
关键词	Adult Acute Stress Nr2b-containing N-methyl-d-aspartate Subtype Glutamate Receptors Anesthetized Rats Ro25-6981 Long-term Potentiation Long-term Depression
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/10875
专题	科研部门_学习记忆的分子神经机制（徐林）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	juncao@vip.163.com; lxu@vip.163.com
作者单位	1.Key Laboratoryof Animal Models and HumanDiseaseMechanisms, and Laboratoryof Learning and Memory,Kunming Institute of Zoology, the Chinese AcademyofSciences,Kunming 2.Graduate Schoolof the ChineseAcademyofSciences, Beijing 3.Mental Health Institute, the 2nd Xiangya Hospitalof Central South University,Changsha,Hunan,PRChina
推荐引用方式 GB/T 7714	Wang MN,Yang Y,Dong ZF,et al. NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo[J]. NEUROREPORT,2006,17(12):1343-1346.
APA	Wang MN.,Yang Y.,Dong ZF.,Cao J.,Xu L.,...&lxu@vip.163.com.(2006).NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo.NEUROREPORT,17(12),1343-1346.
MLA	Wang MN,et al."NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo".NEUROREPORT 17.12(2006):1343-1346.

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