Effects of Neonatal Tactile Stimulation and Maternal Separation on the Anxiety and the Emotional  Memory in Adult Female Rats

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	Effects of Neonatal Tactile Stimulation and Maternal Separation on the Anxiety and the Emotional Memory in Adult Female Rats
其他题名	新生期触觉刺激和母婴分离对雌性大鼠成年后的焦虑和情绪记忆的影响
	Zhang M 1,2; Cai JX*1; caijx@post.kiz.ac.cn
	2006
发表期刊	动物学研究
卷号	27 期号:4 页码:344-350
合作性质	其它
摘要	We investigated the long-lasting effects of early postnatal tactile stimulation (TS) and maternal separation (MS) on the emotional behaviors of adult female rats. A split-litter design was introduced to remove confusing factors such as maternal disturbance. Pups of the non-tactile stimulation (NTS) group did not receive any handling. Pups subjected to the TS treatment were handled and marked for approximately 30 s daily from postnatal days (PND) 2-9 or from PND 10-17. Pups subjected to the MS treatment were...
其他摘要	采用split-litter法对仔鼠进行分组和处理,共5组NTS组(未经实验人员抓握和标记),PND2—9TS组和PND10—17TS组(分别在仔鼠出生后的2—9天、10—17天,每天短暂抓握和标记仔鼠),PND2—9MS组和PND10—17MS组(分别在仔鼠出生后的2—9天、10—17天,除了按TS组相同方式抓握并在不同部位标记外,每天把仔鼠与母鼠分离1h)。待雌鼠成年后,进行明/暗箱测试和一次性被动回避反应测试。结果发现与NTS组相比,PND2—9TS组和PND10—17TS组的雌鼠在明/暗箱测试中停留于明室的累计时间明显较长,在被动回避作业中的重测试潜伏期也明显较长,表明新生期的触觉刺激经历减少雌性大鼠成年后在新异环境中的焦虑,并改善情绪记忆。与相应TS组相比,MS处理组的所有行为指标都无显著性差异,说明短时间母婴分离对雌鼠成年后的焦虑和情绪记忆无明显影响。结果提示,新生期的触觉刺激和母婴分离经历对仔鼠神经系统的发育产生不同的长期效应。
关键词	Rat Tactile Stimulation Maternal Separation Anxiety Emotional Memory Neonatal Period
资助者	This work was supported by National Natural Science Foundation of China (30070251) ; This work was supported by National Natural Science Foundation of China (30070251) ; This work was supported by National Natural Science Foundation of China (30070251) ; This work was supported by National Natural Science Foundation of China (30070251)
收录类别	其他
语种	中文
资助者	This work was supported by National Natural Science Foundation of China (30070251) ; This work was supported by National Natural Science Foundation of China (30070251) ; This work was supported by National Natural Science Foundation of China (30070251) ; This work was supported by National Natural Science Foundation of China (30070251)
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/1087
专题	其他
通讯作者	caijx@post.kiz.ac.cn
作者单位	1.Division of Brain and Behavior, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
推荐引用方式 GB/T 7714	Zhang M,Cai JX*,caijx@post.kiz.ac.cn. Effects of Neonatal Tactile Stimulation and Maternal Separation on the Anxiety and the Emotional Memory in Adult Female Rats[J]. 动物学研究,2006,27(4):344-350.
APA	Zhang M,Cai JX*,&caijx@post.kiz.ac.cn.(2006).Effects of Neonatal Tactile Stimulation and Maternal Separation on the Anxiety and the Emotional Memory in Adult Female Rats.动物学研究,27(4),344-350.
MLA	Zhang M,et al."Effects of Neonatal Tactile Stimulation and Maternal Separation on the Anxiety and the Emotional Memory in Adult Female Rats".动物学研究 27.4(2006):344-350.

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