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	Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in Rhesus macaque brain
	Liu SL1,2,9; Wang ZB1,9; Wu J1; Zhang Y1; Xu KY1,2; Yang LM1; Lv LB1,6; Zheng YT1,6; Chen D3,9; Hu XT1,6,7; Zhang Yi*3,4; Wang XT*5,8; Li JL*1,6; Zhang BW5,9; Tian RR1,9; yizhang@ablife.cc
	2017
发表期刊	Genome Research
卷号	**期号:**页码:published online
摘要	Long noncoding RNA (lncRNA)-mediated epigenetic regulation plays important roles in wide range of biological processes and diseases. Here, we applied comprehensive analyses of RNA-seq and CAGE-seq (cap analysis of gene expression and sequencing) to characterize the dynamic changes in lncRNA expression in rhesus macaque brain in four age groups from postnatal to aged periods. We identified 18 anatomically diverse lncRNA modules and 14 mRNA modules representing spatial, age and sex specificities. Spatiotemporal- and sex-biased changes in lncRNA expression are in general higher than that observed in mRNA expression. A negative correlation between lncRNA and mRNA expression in cerebral cortex was observed, such relationship was further explored and functionally validated. Our findings offer an initial insight into spatial-, age- and sex-biased changes in lncRNA expression in macaque brain, and that the distinct classification of such changes might represent a previously unappreciated regulatory system which potentially contributes to brain development and ageing.
资助者	This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.).
收录类别	SCI
语种	英语
资助者	This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.). ; This study was supported by grants from the Chinese Academy of Sciences (Y406541141 and 1100050210 to J.L.), the Ministry of Science and Technology of China (2015CB755605 to J.L.), and the National Science Foundation of China (91649119 to J.L.); and this study is also supported by grants the Chinese Academy of Sciences (KJ2070000031 to X.W.) and the National Science Foundation of China (91440108 to X.W.); this study is also supported by grants from the Strategic Priority Research Program of CAS (XDB02020005 to X.H.) and the National Science Foundation of China (81471312 to X.H.); this study is also supported by grants from the Appreciate the Beauty of Life, Inc. (ABL2015-02007 to Y. Zhang.).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/11822
专题	科研部门_动物模型与人类重大疾病机理重点实验室 科研部门_分子免疫药理学（郑永唐） 科研部门_神经系统编码（胡新天） 科研部门_表观遗传与神经退行性疾病（李家立） 中国科学院昆明灵长类研究中心
通讯作者	yizhang@ablife.cc
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology, the Chinese Academy of Sciences Kunming, Yunnan, 650223, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences Kunming 650223, China 3.Center for Genome Analysis, ABLife Inc., Wuhan 430075, P. R. China 4.Laboratory for Genome Regulation and Human Health, ABLife Inc., Wuhan 430075, P. R. China 5.School of Life science, CAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Science, University of Science and Technology of China, Hefei ， Anhui 230026, China 6.Kunming Primate Research Center of the Chinese Academy of Sciences Kunming, Yunnan 650223, China 7.CAS Center for Excellence in Brain Science and Intelligence Technology, China 8.CAS Center for Excellence in Molecular Cell Science, China 9.These authors contributed equally to this work
推荐引用方式 GB/T 7714	Liu SL,Wang ZB,Wu J,et al. Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in Rhesus macaque brain[J]. Genome Research,2017,**(**):published online.
APA	Liu SL.,Wang ZB.,Wu J.,Zhang Y.,Xu KY.,...&yizhang@ablife.cc.(2017).Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in Rhesus macaque brain.Genome Research,**(**),published online.
MLA	Liu SL,et al."Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in Rhesus macaque brain".Genome Research **.**(2017):published online.

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