Increased entrances to side compartments indicate incubation of craving in morphine-induced rat and tree shrew CPP models

	Increased entrances to side compartments indicate incubation of craving in morphine-induced rat and tree shrew CPP models
	Sun YM*1,2; Pan ZJ 3; Ma YY 2; y.m.s.sun@vu.nl
	2017
发表期刊	Pharmacology, Biochemistry and Behavior
卷号	159 期号:X 页码:62-68
摘要	In humans, cues associated with the rewarding effect of drugs of abuse induce drug craving and activate drug-associated memories after prolonged abstinence. In animal studies with the self-administration (SA) paradigm, responses to drug-associated cues increase within time after extinction, a phenomenon described as incubation of craving. Conditioned place preference (CPP) is widely used to measure the rewarding effect of drugs and the reward memory thereof. However, little is known whether responses to drug associated cues progressively increase after abstinence from the drugs in the CPP paradigm. To test whether the drug-associated cues could increase specific responses over the abstinence period in the CPP paradigm, we employed the high dose morphine-induced CPP paradigms in rats and tree shrews in the present study. We examined the CPP scores and the entrances to side chambers of the CPP apparatus to check whether they would progressively increase in the CPP paradigms. Twenty-one male adult Sprague-Dawley rats and eight adult male tree shrews were used to establish morphine-induced CPP and another ten rats treated with saline were controls for the rat experiments. After morphine conditioning, rats and tree shrews showed significant higher CPP scores at the first or second post tests than at baseline but then the CPP scores in the abstinence period decreased gradually. The declined CPP scores might due to the repeated exposures or the high doses of morphine used in this study. During the abstinence period, animals with morphine-conditioning experiences entered progressively more times to both side compartments, whereas the number of entrances to side chambers of the saline group in rats had no such significant differences. These findings suggest that progressively increased entrances to the side chambers in the extended abstinence period reflect the incubation of craving in high dose morphine-induced CPP paradigms. Further experiments with lower doses of morphine or other drugs of abuse will be conducted to test whether similar patterns of entrances exist in different species. Also, our data imply that reward memory and drug craving can be distinguished in the CPP paradigm.
关键词	Morphine Cpp Entrances To Side Chambers Reward Memory Drug Craving Incubation Of Drug Craving
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/11947
专题	科研部门_动物模型与人类重大疾病机理重点实验室认知障碍病理学
通讯作者	y.m.s.sun@vu.nl
作者单位	1.Department of Molecular and Cellular Neurobiology, Center for Neurogenomics& Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, Netherlands 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Honghe Health Vocational College, Yunnan, China
推荐引用方式 GB/T 7714	Sun YM*,Pan ZJ,Ma YY,et al. Increased entrances to side compartments indicate incubation of craving in morphine-induced rat and tree shrew CPP models[J]. Pharmacology, Biochemistry and Behavior,2017,159(X):62-68.
APA	Sun YM*,Pan ZJ,Ma YY,&y.m.s.sun@vu.nl.(2017).Increased entrances to side compartments indicate incubation of craving in morphine-induced rat and tree shrew CPP models.Pharmacology, Biochemistry and Behavior,159(X),62-68.
MLA	Sun YM*,et al."Increased entrances to side compartments indicate incubation of craving in morphine-induced rat and tree shrew CPP models".Pharmacology, Biochemistry and Behavior 159.X(2017):62-68.

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