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	Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors
其他题名	zhengyt@mail.kiz.ac.cn ;lirui@scu.edu.cn
	Pu CL1; Luo RH2; Luo J1; Zheng YT*2; Li R*1; Zhang MQ1; Hou XY1; Yan GY1
	2017
发表期刊	Bioorganic & Medicinal Chemistry Letters
卷号	**期号:**页码:Epub ahead of print
摘要	The crystal structure of viral infectivity factor (Vif) was reported recently, which makes it possible to design new inhibitors against Vif by structure-based drug design. Through analysis of the protein surface of Vif, the C2 pocket located in the N-terminal was found, which is suit for developing small molecular inhibitors. Then, in our article, fragment-based virtual screening (FBVS) was conducted and a series of fragments was obtained, among which, Zif-1 bearing indole scaffold and pyridine ring can form H-bonds with Tyr148 and Ile155. Subsequently, 19 derivatives of Zif-1 were synthesized. Through the immune-fluorescence staining and Western blot assays, Zif-15 shows potent activity in inhibiting Vif-mediated A3G degradation. Further docking experiment shows that Zif-15 form H-bond interactions with residues His139, Tyr148 and Ile155. Therefore, Zif-15 is a promising lead compound against Vif that can be used to treat AIDS.
关键词	Apobec3g Degradation Fbvs Indole Derivatives Vif Inhibitor
资助者	We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022).
收录类别	SCI
语种	英语
资助者	We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022). ; We also thank the support of the National Natural Science Foundation of China (81472780, 81102483) and the National Key Program of China during the 12th Five-Year Plan Per- iod (Grant 2012ZX09103101-022).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12008
专题	科研部门_动物模型与人类重大疾病机理重点实验室 科研部门_分子免疫药理学（郑永唐）
作者单位	1.Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041 Sichuan, PR China 2.Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China
推荐引用方式 GB/T 7714	Pu CL,Luo RH,Luo J,et al. Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors[J]. Bioorganic & Medicinal Chemistry Letters,2017,**(**):Epub ahead of print.
APA	Pu CL.,Luo RH.,Luo J.,Zheng YT*.,Li R*.,...&Yan GY.(2017).Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors.Bioorganic & Medicinal Chemistry Letters,**(**),Epub ahead of print.
MLA	Pu CL,et al."Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors".Bioorganic & Medicinal Chemistry Letters **.**(2017):Epub ahead of print.

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