A bimodal activation mechanism underlies scorpion toxin–induced pain

	A bimodal activation mechanism underlies scorpion toxin–induced pain
	Yang SL 1; Yang F 2,3; Luo L 1; Zheng J3; Lai R1; Zhang B 4; Lee BY 3; Li BW 1; jzheng@ucdavis.edu
	2017
发表期刊	Science Advances
卷号	3 期号:8 页码:e1700810
其他摘要	Venomous animals use peptide toxins for hunting and self-defense. To achieve these goals, toxins need to bind to their targets with high affinity due to the small amount that a single bite or sting can deliver. The scorpion toxin BmP01 is linked to sting-induced excruciating pain; however, the reported minimum concentrations for activating TRPV1 channel or inhibiting voltage-gated potassium (Kv) channels (both in the micromolar range) appear too high to be biologically relevant. We show that the effective concentration of BmP01 is highly pH-dependent—it increases by about 10-fold in inhibiting Kv channels upon a 1-U drop in pH but decreases more than 100-fold in activating TRPV1. Mechanistic investigation revealed that BmP01 binds to one of the two proton-binding sites on TRPV1 and, together with a proton, uses a one-two punch approach to strongly activate the nociceptive channel. Because most animal venoms are acidic, proton-facilitated synergistic action may represent a general strategy for maximizing toxin potency.
资助者	This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L.,
收录类别	SCI
语种	英语
资助者	This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L., ; This work was supported by funding from the Ministry of Science and Technology of China (2013CB911304), National Science Foundation of China (331372208 and U1302221), Chinese Academy of Sciences (XDA12040209 and QYZDJ-SSW-SMC012), and Yunnan Province (2015HA023) to R.L. and from the National Science Foundation of China (31640071) and Chinese Academy of Sciences (XDA12020334 and Youth Innovation Promotion Association) to S.Y. This work was also supported by funding from NIH (R01NS072377) to J.Z. and American Heart Association (14POST19820027 and 16PRE26960016) to F.Y. and B.H.L.,
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12009
专题	科研部门_动物模型与人类重大疾病机理重点实验室科研部门_天然药物功能蛋白质学科组（赖仞）
通讯作者	jzheng@ucdavis.edu
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China 3.Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA 4.School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
推荐引用方式 GB/T 7714	Yang SL,Yang F,Luo L,等. A bimodal activation mechanism underlies scorpion toxin–induced pain[J]. Science Advances,2017,3(8):e1700810.
APA	Yang SL.,Yang F.,Luo L.,Zheng J.,Lai R.,...&jzheng@ucdavis.edu.(2017).A bimodal activation mechanism underlies scorpion toxin–induced pain.Science Advances,3(8),e1700810.
MLA	Yang SL,et al."A bimodal activation mechanism underlies scorpion toxin–induced pain".Science Advances 3.8(2017):e1700810.

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