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	Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry
	So HC*1,2; Chau CKL1; Yim SHY4; Sham PC5,6,7,8; Chiu WT3; Ho KS3; Lo CP3; hcso@cuhk.edu.hk
	2017
发表期刊	Nature Neuroscience
卷号	**期号:**页码:published online
摘要	Knowledge of psychiatric disease genetics has advanced rapidly during the past decade with the advent of genome-wide association studies (GWAS). However, less progress has been made in harnessing these data to reveal new therapies. Here we propose a framework for drug repositioning by comparing transcriptomes imputed from GWAS data with drug-induced gene expression profiles from the Connectivity Map database and apply this approach to seven psychiatric disorders. We found a number of repositioning candidates, many supported by preclinical or clinical evidence. Repositioning candidates for a number of disorders were also significantly enriched for known psychiatric medications or therapies considered in clinical trials. For example, candidates for schizophrenia were enriched for antipsychotics, while those for bipolar disorder were enriched for both antipsychotics and antidepressants. These findings provide support for the usefulness of GWAS data in guiding drug discovery.
资助者	This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S.
收录类别	SCI
语种	英语
资助者	This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S. ; This study was partially supported by the Lo-Kwee Seong Biomedical Research Fund and a Direct Grant from the Chinese University of Hong Kong to H.-C.S.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12022
专题	其他
通讯作者	hcso@cuhk.edu.hk
作者单位	1.School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China. 2.KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research of Common Diseases, Kunming Zoology Institute of Zoology and The Chinese University of Hong Kong, China 3.Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China 4.Univeristy of Exeter Medical School, Exeter, UK 5.Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong, China 6.Centre for Genomic Sciences, University of Hong Kong, Pokfulam, Hong Kong, China 7.State Key Laboratory for Cognitive and Brain Sciences, University of Hong Kong, Pokfulam, Hong Kong, China 8.Centre for Reproduction, Development and Growth, University of Hong Kong, Pokfulam, Hong Kong, China.
推荐引用方式 GB/T 7714	So HC*,Chau CKL,Yim SHY,et al. Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry[J]. Nature Neuroscience,2017,**(**):published online.
APA	So HC*.,Chau CKL.,Yim SHY.,Sham PC.,Chiu WT.,...&hcso@cuhk.edu.hk.(2017).Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry.Nature Neuroscience,**(**),published online.
MLA	So HC*,et al."Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry".Nature Neuroscience **.**(2017):published online.

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nn.4618.pdf（363KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文

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