| Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae | |
| Chen H1,3; Zhang R2; Hao XJ*2; Zheng YT*1,4; Luo RH1; Yang LM1; Wang RR1; haoxj@mail.kib.ac.cn; zhengyt@mail.kiz.ac.cn | |
| 2017 | |
| 发表期刊 | Molecules
 |
| 卷号 | 22期号:X页码:e1498 |
| 摘要 | APOBEC3G is a member of the human cytidine deaminase family that restricts Vif-deficient viruses by being packaged with progeny virions and inducing the G to A mutation during the synthesis of HIV-1 viral DNA when the progeny virus infects new cells. HIV-1 Vif protein resists the activity of A3G by mediating A3G degradation. Phorbol esters are plant-derived organic compounds belonging to the tigliane family of diterpenes and could activate the PKC pathway. In this study, we identified an inhibitor 12-O-tricosanoylphorbol-20-acetate (hop-8), a novel ester of phorbol which was isolated from Ostodes katharinae of the family Euphorbiaceae, that inhibited the replication of wild-type HIV-1 and HIV-2 strains and drug-resistant strains broadly both in C8166 cells and PBMCs with low cytotoxicity and the EC50 values ranged from 0.106 μM to 7.987 μM. One of the main mechanisms of hop-8 is to stimulate A3G expressing in HIV-1 producing cells and upregulate the A3G level in progeny virions, which results in reducing the infectivity of the progeny virus. This novel mechanism of hop-8 inhibition of HIV replication might represents a promising approach for developing new therapeutics for HIV infection. |
| 关键词 | Antiviral Agent 12-o-tricosanoylphorbol-20-acetate Hiv Vif Apobec3g Phorbol Ester |
| 资助者 | This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. ; This work was supported in part by grants from the National Science Foundation of China (81471620, 81102483, 81671627), the Key Scientific and Technological Program of China (2014ZX10005-002-006, 2012ZX09103-101-022, 2009ZX09501-029) and of Yunnan Province (2015FB182), and the Chinese Academy of Sciences (CASIMM0320163020) and Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/12037 |
| 专题 | 科研部门_动物模型与人类重大疾病机理重点实验室 科研部门_分子免疫药理学（郑永唐） |
| 通讯作者 | haoxj@mail.kib.ac.cn; zhengyt@mail.kiz.ac.cn |
| 作者单位 | 1.Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, Yunnan, Chin 4.KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University, Suzhou 215006, Jiangsu, China |
| 推荐引用方式 GB/T 7714 | Chen H,Zhang R,Hao XJ*,et al. Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae[J]. Molecules,2017,22(X):e1498. |
| APA | Chen H.,Zhang R.,Hao XJ*.,Zheng YT*.,Luo RH.,...&zhengyt@mail.kiz.ac.cn.(2017).Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae.Molecules,22(X),e1498. |
| MLA | Chen H,et al."Anti-HIV Activities and Mechanism of 12-O-Tricosanoylphorbol-20-acetate, a Novel Phorbol Ester from Ostodes katharinae".Molecules 22.X(2017):e1498. |
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