| Detection of breed specific copy number variations in domestic chicken genome. | |
| Sohrabi SS1,2; Mohammadabadi M3; Wu DD4,5; Esmailizadeh A*1,6; aliesmaili@uk.ac.ir | |
| 2017 | |
| 发表期刊 | Genome
 |
| 卷号 | **期号:**页码:Epub ahead of print |
| 摘要 | Copy number variations (CNVs) are important large scale variants that are widespread in the genome and may contribute to phenotypic variation. Detection and characterization of CNVs can provide new insights into the genetic basis of important traits. Here, we performed whole genome short read sequence analysis to identify CNVs in two indigenous and commercial chicken breeds and evaluate the impact of the identified CNVs on breed specific traits. After filtration, a total of 12955 CNVs spanning (on average) about 9.42% of the chicken genome were found that made up 5467 CNV regions (CNVRs). Chicken quantitative trait loci (QTL) datasets and Ensembl gene annotations were used as resources for the estimation of potential phenotypic effects of our CNVRs on breed specific traits. In total, 34% of our detected CNVRs were also detected in earlier CNV studies. These CNVRs partly overlap with several previously reported QTL and gene ontology terms associated with some important traits, including shank length QTL in Creeper specific CNVRs and body weight and egg production characteristics as well as growth of muscles and body organs gene terms in the Arian commercial breed. Our findings provide new insights into the genomic structure of the chicken genome for an improved understanding of the potential roles of CNVRs in differentiating between breeds or lines. |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/12046 |
| 专题 | 遗传资源与进化国家重点实验室 科研部门_进化与发育转录组学（吴东东） |
| 通讯作者 | aliesmaili@uk.ac.ir |
| 作者单位 | 1.Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, PB 76169-133, Kerman, Iran., Kerman, Iran (the Islamic Republic of) 2.Young Researchers Society, Shahid Bahonar University of Kerman, PB 76169-133, Kerman, Iran (the Islamic Republic of) 3.Department of Animal Science, Faculty of Agriculture, Shahid Bahonar University of Kerman, PB 76169-133, Kerman, Iran., Kerman, Iran (the Islamic Republic of) 4.State Key Laboratory of Genetic Resources and Evolution & Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China, Kunming, China 5.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China, Kunming, China 6.State Key Laboratory of Genetic Resources and Evolution & Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China, Kunming, China |
| 推荐引用方式 GB/T 7714 | Sohrabi SS,Mohammadabadi M,Wu DD,et al. Detection of breed specific copy number variations in domestic chicken genome.[J]. Genome,2017,**(**):Epub ahead of print. |
| APA | Sohrabi SS,Mohammadabadi M,Wu DD,Esmailizadeh A*,&aliesmaili@uk.ac.ir.(2017).Detection of breed specific copy number variations in domestic chicken genome..Genome,**(**),Epub ahead of print. |
| MLA | Sohrabi SS,et al."Detection of breed specific copy number variations in domestic chicken genome.".Genome **.**(2017):Epub ahead of print. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2017101005.pdf（520KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论